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Articles Published Processes
3/20/2015 10:48:00 AM | Browse: 975 | Download: 1297
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Received |
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2014-07-23 20:30 |
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Peer-Review Started |
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2014-07-25 20:44 |
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To Make the First Decision |
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2014-08-28 14:41 |
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Return for Revision |
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2014-08-29 14:19 |
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Revised |
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2014-09-29 12:18 |
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Second Decision |
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2014-11-10 15:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-10 16:18 |
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Articles in Press |
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2014-11-10 16:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-11 16:13 |
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Publish the Manuscript Online |
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2015-03-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Development of cancer-initiating cells and immortalized cells with genomic instability
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ken-ichi Yoshioka, Yuko Atsumi, Hitoshi Nakagama and Hirobumi Teraoka |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Cancer Center Research and Development Fund Grant |
23-C-10 |
| Scientific Research MEXT KAKENHI |
20770136 |
| JSPS Fellows |
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| Corresponding Author |
Ken-ichi Yoshioka, PhD, Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045,
Japan. kyoshiok@ncc.go.jp
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| Key Words |
ARF/p53 module; Cancer stem cells; Cancer-initiating cells; Differentiation; Genomic instability; H2AX |
| Core Tip |
Cancer usually develops in conjunction with genomic instability and multiple genetic mutations. Only a small number of cells, called cancer-initiating cells (CICs), are the progenitors of cancerous tissue; but how genomic instability and genetic mutations prompt CICs to develop is still unclear. Recent investigations have uncovered the existence of a pathway that could be responsible. This review explores how that pathway might induce the development of CICs, the tumor suppression mechanisms that must be abrogated in order for malignancies to occur, and the role of the alternative reading frame of CDKN2A (ARF)/p53 module/p53 module in protecting normal cells from oncologic transformation. |
| Publish Date |
2015-03-20 10:47 |
| Citation |
Yoshioka K, Atsumi Y, Nakagama H, Teraoka H. Development of cancer-initiating cells and immortalized cells with genomic instability. World J Stem Cells 2015; 7(2): 483-489 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i2/483.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i2.483 |
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