Publication Name	World Journal of Biological Chemistry
Manuscript ID	16830
Country	Germany

Received	2015-01-29 21:33
Peer-Review Started	2015-01-30 19:10
To Make the First Decision	2015-03-06 10:27
Return for Revision	2015-03-11 20:06
Revised	2015-03-30 19:32
Second Decision	2015-06-08 11:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-06-16 16:51
Articles in Press	2015-06-16 16:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-04 10:15
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Allergy
Manuscript Type	Editorial
Article Title	Lack of new antiinfective agents: Passing into the pre-antibiotic age?
Manuscript Source	Invited Manuscript
All Author List	Klaus Brandenburg and Tobias Schürholz
Funding Agency and Grant Number	Funding Agency Grant Number German ministry BMBF 01GUO824 German ministry BMBF 01GUO826
Corresponding Author	Klaus Brandenburg, MS, PhD, Professor, Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, Parkallee 10, D-23845 Borstel, Germany. kbrandenburg@fz-borstel.de
Key Words	Antimicrobial resistance; Antibiotics; Sepsis; Antimicrobial peptides; Lipoproteins; Inflammation; Cytokines; Endotoxins
Core Tip	The dramatic increase in multiresistance of relevant pathogenic bacteria can be assumed to be one of the main global health care problems of the 21st century. At the same time, the development of new antibiotics decreases considerably from which a significant lack in the health supply for combating infections can be scheduled. In this paper, alternative strategies are discussed which are focused mainly on the development and application of antimicrobial peptides. These can easily be synthesized in high amounts under moderate costs, have usually a high therapeutic index, and do not have a tendency for resistance emergence. Recent developments are presented from which it may be deduced that the most serious form of a bacterial infection, sepsis and septic shock, may be treatable in near future.
Publish Date	2015-08-26 11:07
Citation	Brandenburg K, Schürholz T. Lack of new antiinfective agents: Passing into the pre-antibiotic age? World J Biol Chem 2015; 6(3): 71-77
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/71.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.71

Full Article (PDF)	WJBC-6-71.pdf
Full Article (Word)	WJBC-6-71.doc
Manuscript File	16830-Review.docx
Answering Reviewers	16830-Answering reviewers.pdf
Audio Core Tip	16830-Audio core tip.wav
Conflict-of-Interest Disclosure Form	16830-Conflict-of-interest statement.pdf
Copyright License Agreement	16830-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20150129173709.docx
Peer-review Report	16830-Peer-review(s).pdf
Scientific Misconduct Check	16830-Scientific misconduct check.pdf
Scientific Editor Work List	16830-Scientific editor work list.pdf