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Articles Published Processes
2/15/2016 11:40:00 AM | Browse: 1336 | Download: 2450
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Received |
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2015-03-14 13:51 |
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Peer-Review Started |
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2015-03-16 08:36 |
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To Make the First Decision |
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2015-04-10 17:41 |
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Return for Revision |
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2015-04-17 09:54 |
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Revised |
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2015-04-24 23:14 |
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Second Decision |
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2015-06-12 16:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-01-22 16:23 |
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Articles in Press |
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2016-01-22 16:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-25 09:16 |
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Publish the Manuscript Online |
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2016-02-15 11:40 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hui-Chen Wu, Jing Shen, Hwai-I Yang, Wei-Yann Tsai, Chien-Jen Chen and Regina M Santella |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health grants |
RO1ES005116 (to Santella RM) |
| National Institutes of Health grants |
P30ES009089 (to Santella RM) |
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| Corresponding Author |
Dr. Hui-Chen Wu, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 650 West 168th St, New York, NY 10032, United States. hw2057@columbia.edu
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| Key Words |
DNA methylation; Epigenetics; Hepatitis B virus; Hepatocellular carcinoma; White blood cell DNA |
| Core Tip |
Hepatocellular carcinoma (HCC) is a highly fatal disease thus, the identification of biomarkers that could predict risk for development could enhance screen-ing/early detection and prognosis. DNA methylation alterations are well established in HCC but whether changes in DNA methylation in white blood cells (WBC) are associated with increased risk of developing HCC is unknown. Taking advantage of a cancer screening program in Taiwan, we measured baseline WBC DNA methylation in prospectively collected blood samples at 96 CpG sites that were identified as differentially methy-lated in HCC tumors compared to adjacent tissues. Three were significantly associated with later development of HCC suggesting potential utility as a marker of risk.
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| Publish Date |
2016-02-15 11:40 |
| Citation |
Wu HC, Shen J, Yang HI, Tsai WY, Chen CJ, Santella RM. Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan. World J Hepatol 2016; 8(5): 301-306 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i5/301.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i5.301 |
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