Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	18190
Country	Thailand

Received	2015-04-10 15:51
Peer-Review Started	2015-04-12 00:30
To Make the First Decision	2015-07-02 13:29
Return for Revision	2015-07-10 13:52
Revised	2015-07-22 23:09
Second Decision	2015-09-02 15:41
Accepted by Journal Editor-in-Chief	2015-09-03 07:04
Accepted by Executive Editor-in-Chief	2015-09-16 18:46
Articles in Press	2015-09-16 18:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-26 14:30
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Current understanding of the neuropathophysiology of pain in chronic pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Amporn Atsawarungruangkit and Supot Pongprasobchai
Funding Agency and Grant Number
Corresponding Author	Supot Pongprasobchai, MD, Division of Gastroenterology, Department of Medicine, Siriraj Hospital, 2 Pran-Nok Road, Bangkok 10700, Thailand. supot.pon@mahidol.ac.th
Key Words	Neurobiology; Neuropathophysiology; Pain; Pancreatic pain; Chronic pancreatitis
Core Tip	Abdominal pain is the main symptom of patients with chronic pancreatitis (CP), yet the under-lying mechanisms are not well understood. The emerging explanations of pain in CP are trending toward neurobiological theories. This article reviews these emerging concepts and their potential implications for the development of new treatments for pain in CP. Three major concepts attempting to explain the pathogenesis of CP pain: Pancreatic nociception and sensitization-induced pain, neuropathic remodeling, and central mechanism of pancreatitis pain are summarized, along with the specific molecules involved in each and potential therapeutic targets.
Publish Date	2015-11-17 12:17
Citation	Atsawarungruangkit A, Pongprasobchai S. Current understanding of the neuropathophysiology of pain in chronic pancreatitis. World J Gastrointest Pathophysiol 2015; 6(4): 193-202
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/193.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.193

Full Article (PDF)	WJGP-6-193.pdf
Full Article (Word)	WJGP-6-193.doc
Manuscript File	18190-Review.docx
Answering Reviewers	18190-Answering reviewers.pdf
Audio Core Tip	18190-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	18190-Conflict-of-interest statement.pdf
Copyright License Agreement	18190-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	18190-Language certificate.pdf
Peer-review Report	18190-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	18190-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	18190-Scientific misconduct check.pdf
Scientific Editor Work List	18190-Scientific editor work list.pdf