Publication Name	World Journal of Gastroenterology
Manuscript ID	19232
Country	United States

Received	2015-04-30 19:13
Peer-Review Started	2015-05-08 11:38
To Make the First Decision	2015-07-14 11:42
Return for Revision	2015-07-14 20:29
Revised	2015-08-15 06:05
Second Decision	2015-10-23 16:35
Accepted by Journal Editor-in-Chief	2015-10-26 11:12
Accepted by Executive Editor-in-Chief	2015-12-01 08:28
Articles in Press	2015-12-01 08:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-15 20:31
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Xenobiotics and loss of tolerance in primary biliary cholangitis
Manuscript Source	Invited Manuscript
All Author List	Jinjun Wang, Guoxiang Yang, Alana Mari Dubrovsky, Jinjung Choi and Patrick SC Leung
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health grants DK39588 (in part) National Institutes of Health grants DK090019 (in part) National Institutes of Health grants DK067003 (in part)
Corresponding Author	Patrick SC Leung, PhD, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, United States. psleung@ucdavis.edu
Key Words	Antimitochondrial autoantibodies; Primary biliary cholangitis; Pyruvate dehydrogenase E2; Breaking of tolerance; Xenobiotics
Core Tip	Environment influences immune functions. In this paper, we examine how environmental chemicals can trigger autoimmunity in an organ specific autoimmune disease, primary biliary cholangitis (PBC). PBC is liver specific autoimmune disease characterized by high titer of anti-mitochondrial autoantibodies directed against the E2 subunit of pyruvate dehydrogenase (PDC-E2) lipoyl domain. Here, we present experimental evidence from quantitative structure-activity relationship and animal models that xenobiotic modification of the PDC-E2 lipoyl domain could lead to loss of self-tolerance and is a pivotal event in the initial etiology of PBC in genetically susceptible hosts.
Publish Date	2015-12-31 13:27
Citation	Wang J, Yang G, Dubrovsky AM, Choi J, Leung PSC. Xenobiotics and loss of tolerance in primary biliary cholangitis. World J Gastroenterol 2016; 22(1): 338-348
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/338.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.338

Full Article (PDF)	WJG-22-338.pdf
Full Article (Word)	WJG-22-338.doc
Manuscript File	19232-Review.docx
Answering Reviewers	19232-Answering reviewers.pdf
Audio Core Tip	19232-Audio core tip.mp3
Copyright License Agreement	19232-Copyright assignment.pdf
Peer-review Report	19232-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19232-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19232-Scientific misconduct check.pdf
Scientific Editor Work List	19232-Scientific editor work list.pdf