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11/12/2015 7:10:00 PM | Browse: 1091 | Download: 1917
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 20853
Country United States
Received
2015-06-24 08:29
Peer-Review Started
2015-06-26 17:18
To Make the First Decision
2015-08-16 17:31
Return for Revision
2015-08-26 08:50
Revised
2015-09-06 00:54
Second Decision
2015-10-08 12:24
Accepted by Journal Editor-in-Chief
2015-10-09 00:42
Accepted by Executive Editor-in-Chief
2015-10-19 15:35
Articles in Press
2015-10-19 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-26 11:36
Publish the Manuscript Online
2015-11-12 18:51
ISSN 2150-5349 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Pharmacotherapy for the management of achalasia: Current status, challenges and future directions
Manuscript Source Invited Manuscript
All Author List Ammar Nassri and Zeeshan Ramzan
Funding Agency and Grant Number
Corresponding Author Zeeshan Ramzan, MD, Assistant Profes­sor, Gastrointestinal Section, Department of Internal Medicine, VA North Texas Healthcare System, 4500 S. Lancaster Road, Dallas, TX 75216, United States. zeeshanramzan@hotmail.com
Key Words Botulinum toxin; Botox; Achalasia; Pharmacotherapy; Sprouting inhibitors
Core Tip Botulinum toxin (BT) injection is the most common and effective pharmacological therapy used in the treatment of achalasia, and is commonly used in the elderly, those with multiple comorbidities, patients at high risk for surgery and as a salvage therapy. This article discusses new advances related to the pharmacological management of achalasia that may help to optimize minimally invasive treatment approaches in patients with achalasia, and discusses improvements in endoscopic injection techniques, the use of sclerosants, new BT formulations, alternate serotypes, sprouting inhibitors and designer recombinant BT formulations.
Publish Date 2015-11-12 18:51
Citation Nassri A, Ramzan Z. Pharmacotherapy for the management of achalasia: Current status, challenges and future directions. World J Gastrointest Pharmacol Ther 2015; 6(4): 145-155
URL http://www.wjgnet.com/2150-5349/full/v6/i4/145.htm
DOI http://dx.doi.org/10.4292/wjgpt.v6.i4.145
Full Article (PDF) WJGPT-6-145.pdf
Full Article (Word) WJGPT-6-145.doc
Manuscript File 20853-Review.docx
Answering Reviewers 20853-Answering reviewers.pdf
Audio Core Tip 20853-Audio core tip.wav
Conflict-of-Interest Disclosure Form 20853-Conflict-of-interest statement.pdf
Copyright License Agreement 20853-Copyright assignment.pdf
Supplementary Material Supplementary_Material_20150624065049.docx
Peer-review Report 20853-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20853-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20853-Scientific misconduct check.pdf
Scientific Editor Work List 20853-Scientific editor work list.pdf