Publication Name	World Journal of Gastroenterology
Manuscript ID	22429
Country	China

Received	2015-09-06 08:23
Peer-Review Started	2015-09-06 23:02
To Make the First Decision	2015-11-05 10:34
Return for Revision	2015-11-09 08:56
Revised	2015-11-17 21:35
Second Decision	2015-12-03 08:07
Accepted by Journal Editor-in-Chief	2015-12-03 12:39
Accepted by Executive Editor-in-Chief	2015-12-14 16:10
Articles in Press	2015-12-14 16:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-24 03:57
Typeset the Manuscript	2016-01-18 17:04
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Gui-Mei Kong, Wen-Hua Tao, Ya-Li Diao, Peng-Hua Fang, Ji-Jun Wang, Ping Bo and Feng Qian
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30801497 National Natural Science Foundation of China 81272537 National Natural Science Foundation of China 81472815 Natural Science Fund for Colleges and Universities in Jiangsu Province 11KJD360003
Corresponding Author	Feng Qian, MD, Department of Jiangsu Key laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Medical School of Yangzhou University, No. 88 Road, Yangzhou 225001, Jiangsu province, China. amawy@126.com
Key Words	Melittin; Gastric cancer; Mitochondrial; Apoptosis; Cytochrome C
Core Tip	SGC-7901 cells stimulated by melittin dis-played typical apoptotic morphology. In addition, reactive oxygen species release was induced, and the mitochondrial membrane permeability was rendered irreversibly open, causing a reduction in the mitochondrial membrane potential. These changes increased the release of cytochrome C, apoptosis-inducing factor, and endonuclease G and decreased second mitochondria-derived activator of caspases (Smac)/direct IAP binding protein with low isoelectric point (Diablo), which activated downstream caspase-3 and induced apoptosis.
Publish Date	2016-03-14 08:44
Citation	Kong GM, Tao WH, Diao YL, Fang PH, Wang JJ, Bo P, Qian F. Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. World J Gastroenterol 2016; 22(11): 3186-3195
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3186.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3186

Full Article (PDF)	WJG-22-3186.pdf
Full Article (Word)	WJG-22-3186.doc
Manuscript File	22429-Review.doc
Answering Reviewers	22429-Answering reviewers.pdf
Audio Core Tip	22429-Audio core tip.amr
Biostatistics Review Certificate	22429-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20150905190636.docx
Conflict-of-Interest Disclosure Form	22429-Conflict-of-interest statement.pdf
Copyright License Agreement	22429-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150905190649.docx
Institutional Animal Care and Use Committee Approval Form or Document	22429-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	22429-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150905190836.pdf
Supplementary Material	Supplementary_Material_20150905191140.docx
Peer-review Report	22429-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22429-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22429-Scientific misconduct check.pdf
Scientific Editor Work List	22429-Scientific editor work list.pdf