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Articles Published Processes
7/6/2016 4:53:00 PM | Browse: 1042 | Download: 1863
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Received |
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2016-01-14 08:42 |
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Peer-Review Started |
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2016-01-18 11:14 |
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To Make the First Decision |
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2016-03-07 17:12 |
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Return for Revision |
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2016-03-22 11:13 |
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Revised |
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2016-04-16 01:03 |
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Second Decision |
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2016-04-25 13:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-05-23 16:17 |
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Articles in Press |
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2016-05-23 16:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-06-08 14:45 |
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Typeset the Manuscript |
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2016-06-30 11:57 |
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Publish the Manuscript Online |
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2016-07-06 16:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ning-Li Chai, Xiao-Bin Zhang, Si-Wen Chen, Ke-Xing Fan and En-Qiang Linghu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81072913 |
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| Corresponding Author |
En-Qiang Linghu, MD, Department of Gastroenterology, PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com |
| Key Words |
Liver fibrosis; Mesenchymal stem cells; Kupffer cells; Interleukin-4; Dimethylnitrosamine; DMN |
| Core Tip |
Dysregulation of the M1/M2 macrophages phenotypic balance governs the pathogenesis of liver fibrosis. Flow cytometry, immunohistochemistry and liver function tests showed that umbilical cord-derived mesenchymal stem cells (UC-MSCs) could promote the mobilization of M1 Kupffer cells (KCs) into the M2 phenotype in vivo and in vitro thereby ameliorating liver inflammation and liver fibrosis. Thus, UC-MSC transfusion yielded promising results with regard to reversal of liver injury and alleviated liver fibrosis by promoting KC mobilization and hepatocyte differentiation. The application of UC-MSCs might provide a new tool for cell therapy of liver fibrosis. |
| Publish Date |
2016-07-06 16:53 |
| Citation |
Chai NL, Zhang XB, Chen SW, Fan KX, Linghu EQ. Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats. World J Gastroenterol 2016; 22(26): 6036-6048 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i26/6036.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i26.6036 |
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