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5/19/2016 9:54:00 AM | Browse: 416 | Download: 622
Publication Name World Journal of Gastroenterology
Manuscript ID 24455
Country/Territory New Zealand
2016-01-25 08:59
Peer-Review Started
2016-01-25 09:55
To Make the First Decision
2016-02-18 11:47
Return for Revision
2016-02-19 13:58
2016-03-05 23:27
Second Decision
2016-03-11 08:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-18 17:32
Articles in Press
2016-03-18 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-03-29 10:38
Typeset the Manuscript
2016-05-04 16:52
Publish the Manuscript Online
2016-05-17 10:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction
Manuscript Source Invited Manuscript
All Author List Michael JJ Chu, Rakesh Premkumar, Anthony JR Hickey, Yannan Jiang, Brett Delahunt, Anthony RJ Phillips and Adam SJR Bartlett
Funding Agency and Grant Number
Funding Agency Grant Number
University of Auckland Faculty Research Development Fund
Corresponding author Michael JJ Chu, PhD, Candidate/General Surgical Resident, Department of Surgery, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. michaeljjc@gmail.com
Keywords Mitochondrial respiration; Fatty liver; Liver ischemia; Oxidative phosphorylation; Liver injury; Hepatic steatosis; Ischemic preconditioning
Core Tip We report a detailed mitochondrial function analysis of dietary-induced hepatic steatosis, which was not choline-deficient, during warm ischemia and after ischemia-reperfusion injury. We evaluated mitochondrial complex?Ⅰ?and Ⅱ activities as well as the impact of ischemic preconditioning on mitochondrial function. This study demonstrates that steatotic livers have decreased Complex-Ⅰ?activity at baseline and that Complex-Ⅰ?function is further impaired after warm ischemia-reperfusion injury. Ischemic preconditioning was unable to attenuate the harmful effect of ischemia-reperfusion on mitochondrial function.
Publish Date 2016-05-17 10:45
Citation Chu MJJ, Premkumar R, Hickey AJR, Jiang Y, Delahunt B, Phillips ARJ, Bartlett ASJR. Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction. World J Gastroenterol 2016; 22(19): 4673-4684
Url http://www.wjgnet.com/1007-9327/full/v22/i19/4673.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i19.4673
Full Article (PDF) WJG-22-4673.pdf
Full Article (Word) WJG-22-4673.doc
Manuscript File 24455-Review.docx
Answering Reviewers 24455-Answering reviewers.pdf
Audio Core Tip 24455-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 24455-Conflict-of-interest statement.pdf
Copyright License Agreement 24455-Copyright assignment.pdf
Data Sharing Statement 24455-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 24455-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 24455-Institutional animal care and use committee statement.pdf
Supplementary Material Supplementary_Material_20160123181025.docx
Peer-review Report 24455-Peer-review(s).pdf
Scientific Misconduct Check 24455-Scientific misconduct check.pdf
Scientific Editor Work List 24455-Scientific editor work list.pdf