BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/19/2016 9:54:00 AM | Browse: 1296 | Download: 2987
 |
Received |
|
2016-01-25 08:59 |
|
Peer-Review Started |
|
2016-01-25 09:55 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2016-02-19 13:58 |
|
Revised |
|
2016-03-05 23:27 |
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2016-03-11 08:04 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2016-03-18 17:32 |
|
Articles in Press |
|
2016-03-18 17:33 |
|
Edit the Manuscript by Language Editor |
|
2016-03-29 10:38 |
|
Typeset the Manuscript |
|
2016-05-04 16:52 |
|
Publish the Manuscript Online |
|
2016-05-17 10:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Michael JJ Chu, Rakesh Premkumar, Anthony JR Hickey, Yannan Jiang, Brett Delahunt, Anthony RJ Phillips and Adam SJR Bartlett |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Auckland Faculty Research Development Fund |
|
|
| Corresponding Author |
Michael JJ Chu, PhD, Candidate/General Surgical Resident, Department of Surgery, University of Auckland, Private Bag 92019, Auckland 1142,
New Zealand. michaeljjc@gmail.com
|
| Key Words |
Mitochondrial respiration; Fatty liver; Liver ischemia; Oxidative phosphorylation; Liver injury; Hepatic steatosis; Ischemic preconditioning |
| Core Tip |
We report a detailed mitochondrial function analysis of dietary-induced hepatic steatosis, which was not choline-deficient, during warm ischemia and after ischemia-reperfusion injury. We evaluated mitochondrial complex?Ⅰ?and Ⅱ activities as well as the impact of ischemic preconditioning on mitochondrial function. This study demonstrates that steatotic livers have decreased Complex-Ⅰ?activity at baseline and that Complex-Ⅰ?function is further impaired after warm ischemia-reperfusion injury. Ischemic preconditioning was unable to attenuate the harmful effect of ischemia-reperfusion on mitochondrial function.
|
| Publish Date |
2016-05-17 10:45 |
| Citation |
Chu MJJ, Premkumar R, Hickey AJR, Jiang Y, Delahunt B, Phillips ARJ, Bartlett ASJR. Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction. World J Gastroenterol 2016; 22(19): 4673-4684 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i19/4673.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i19.4673 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
