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Articles Published Processes
5/19/2016 9:54:00 AM | Browse: 1099 | Download: 2264
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Received |
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2016-01-25 08:59 |
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Peer-Review Started |
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2016-01-25 09:55 |
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To Make the First Decision |
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2016-02-18 11:47 |
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Return for Revision |
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2016-02-19 13:58 |
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Revised |
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2016-03-05 23:27 |
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Second Decision |
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2016-03-11 08:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-18 17:32 |
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Articles in Press |
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2016-03-18 17:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-29 10:38 |
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Typeset the Manuscript |
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2016-05-04 16:52 |
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Publish the Manuscript Online |
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2016-05-17 10:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Michael JJ Chu, Rakesh Premkumar, Anthony JR Hickey, Yannan Jiang, Brett Delahunt, Anthony RJ Phillips and Adam SJR Bartlett |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Auckland Faculty Research Development Fund |
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| Corresponding Author |
Michael JJ Chu, PhD, Candidate/General Surgical Resident, Department of Surgery, University of Auckland, Private Bag 92019, Auckland 1142,
New Zealand. michaeljjc@gmail.com
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| Key Words |
Mitochondrial respiration; Fatty liver; Liver ischemia; Oxidative phosphorylation; Liver injury; Hepatic steatosis; Ischemic preconditioning |
| Core Tip |
We report a detailed mitochondrial function analysis of dietary-induced hepatic steatosis, which was not choline-deficient, during warm ischemia and after ischemia-reperfusion injury. We evaluated mitochondrial complex?Ⅰ?and Ⅱ activities as well as the impact of ischemic preconditioning on mitochondrial function. This study demonstrates that steatotic livers have decreased Complex-Ⅰ?activity at baseline and that Complex-Ⅰ?function is further impaired after warm ischemia-reperfusion injury. Ischemic preconditioning was unable to attenuate the harmful effect of ischemia-reperfusion on mitochondrial function.
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| Publish Date |
2016-05-17 10:45 |
| Citation |
Chu MJJ, Premkumar R, Hickey AJR, Jiang Y, Delahunt B, Phillips ARJ, Bartlett ASJR. Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-Ⅰ dysfunction. World J Gastroenterol 2016; 22(19): 4673-4684 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i19/4673.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i19.4673 |
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