Publication Name	World Journal of Orthopedics
Manuscript ID	24752
Country	United States

Received	2016-02-09 11:49
Peer-Review Started	2016-02-14 14:10
To Make the First Decision	2016-03-21 13:56
Return for Revision	2016-03-21 18:17
Revised	2016-04-04 01:38
Second Decision	2016-04-12 17:13
Accepted by Journal Editor-in-Chief	2016-04-13 14:03
Accepted by Executive Editor-in-Chief	2016-04-22 16:33
Articles in Press	2016-04-22 16:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-05-24 14:22
Publish the Manuscript Online	2016-06-13 09:08

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Antimicrobial technology in orthopedic and spinal implants
Manuscript Source	Invited Manuscript
All Author List	Adam EM Eltorai, Jack Haglin, Sudheesha Perera, Bielinsky A Brea, Roy Ruttiman, Dioscaris R Garcia, Christopher T Born and Alan H Daniels
Funding Agency and Grant Number
Corresponding Author	Alan H Daniels, MD, Assistant Professor, Department of Orthopedic Surgery, Warren Alpert Medical School, Brown University, 100 Butler Drive, Providence, RI 02906, United States. alan_daniels@brown.edu
Key Words	Antimicrobial; Coated implants; Antibiotic; Antiseptic; Nano-silver; Photoactive
Core Tip	Infections can hinder orthopedic implant func-tion and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines the latest orthopedic implant antimicrobial technologies-including updates on chitosan coatings, photoactive-based coatings, electrospinning technology, integrated biofilms-highlighting the current applications, supporting evidence, and clinically-pro-mising future directions.
Publish Date	2016-06-13 09:08
Citation	Eltorai AEM, Haglin J, Perera S, Brea BA, Ruttiman R, Garcia DR, Born CT, Daniels AH. Antimicrobial technology in orthopedic and spinal implants. World J Orthop 2016; 7(6): 361-369
URL	http://www.wjgnet.com/2218-5836/full/v7/i6/361.htm
DOI	http://dx.doi.org/10.5312/wjo.v7.i6.361

Full Article (PDF)	WJO-7-361.pdf
Full Article (Word)	WJO-7-361.doc
Manuscript File	24752-Review.docx
Answering Reviewers	24752-Answering reviewers.pdf
Audio Core Tip	24752-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	24752-Conflict-of-interest statement.pdf
Copyright License Agreement	24752-Copyright assignment.pdf
Peer-review Report	24752-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	24752-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	24752-Scientific misconduct check.pdf
Scientific Editor Work List	24752-Scientific editor work list.pdf