Publication Name	World Journal of Nephrology
Manuscript ID	25453
Country	United Kingdom

Received	2016-03-17 09:41
Peer-Review Started	2016-03-18 17:41
First Decision by Editorial Office Director
Return for Revision	2016-04-18 17:30
Revised	2016-05-02 10:33
Publication Fee Transferred
Second Decision by Editor	2016-06-27 17:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-07-13 13:56
Articles in Press	2016-07-13 13:56
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-26 15:38
Publish the Manuscript Online	2016-09-01 09:16

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Observational Study
Article Title	Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?
Manuscript Source	Invited Manuscript
All Author List	Elizabeth Oei, Klara Paudel, Annemarie Visser, Hazel Finney and Stanley L Fan
Funding Agency and Grant Number
Corresponding Author	Dr. Stanley L Fan, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, Whitechapel Road, Whitechapel, London E1 1BB, United Kingdom. s.fan@qmul.ac.uk
Key Words	Bioimpedance; Fluid status; Peritoneal dialysis; Mortality; Overhydration; Cardiac troponin
Core Tip	Overhydration measured by bioimpedance spectroscopy is an independent predictor of death in peritoneal dialysis patients. Most studies on this topic provide only a single baseline bioimpedance assessment. We present longitudinal data showing increased cardiac mortality in overhydrated patients, and significant correlation of overhydration with cardiac troponin-T (cTnT) levels. Over 6 mo, these patients had a mean of 7.4 body composition monitor readings and 3.4 cTnT assessments. Patients whose hydration status improved showed a corresponding improvement in cTnT. While observational studies cannot define causality, our results show overhydration is associated with cardiac mortality, and suggest overhydration may be a reversible risk factor.
Publish Date	2016-09-01 09:16
Citation	Oei E, Paudel K, Visser A, Finney H, Fan SL. Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible? World J Nephrol 2016; 5(5): 448-454
URL	http://www.wjgnet.com/2220-6124/full/v5/i5/448.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i5.448

Full Article (PDF)	WJN-5-448.pdf
Full Article (Word)	WJN-5-448.doc
Manuscript File	25453-Review.docx
Answering Reviewers	25453-Answering reviewers.pdf
Audio Core Tip	25453-Audio core tip.mp3
Biostatistics Review Certificate	Biostatistics_Statement_20160316210131.docx
Conflict-of-Interest Disclosure Form	25453-Conflict-of-interest statement.pdf
Copyright License Agreement	25453-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160316210142.docx
Institutional Review Board Approval Form or Document	25453-Institutional review board statement.pdf
Peer-review Report	25453-Peer-review(s).pdf
Scientific Misconduct Check	25453-Scientific misconduct check.pdf
Scientific Editor Work List	25453-Scientific editor work list.pdf