| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kohei Matsumoto, Hiroya Ueyama, Kenshi Matsumoto, Yoichi Akazawa, Hiroyuki Komori, Tsutomu Takeda, Takashi Murakami, Daisuke Asaoka, Mariko Hojo, Natsumi Tomita, Akihito Nagahara, Yoshiaki Kajiyama, Takashi Yao and Sumio Watanabe |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Kohei Matsumoto, MD, Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. khmatsu@juntendo.ac.jp |
| Key Words |
Alpha-fetoprotein-producing gastric cancer; Gastric cancer with enteroblastic differentiation; Early gastric cancer; Glypican 3; SALL4 |
| Core Tip |
We evaluated the comparison of clinicopathological features between 6 cases of early stage gastric cancer with enteroblastic differentiation (GCED) and 186 cases of early stage conventional gastric cancer (CGC: well/ moderately differentiated adenocarcinoma). Lymphatic, venous, and submucosal invasion rates were higher in GCED than CGC (33.3% vs 2.3%, 66.6% vs 0.4%, 66.6% vs 11.4% respectively, P < 0.01). In addition, Glypican 3 was the most sensitive marker for GCED (positivity, 83.3%), immunohistochemically. GCED has high malignant potential even at an early stage, and preoperative diagnosis is considered difficult. Further investigations are needed to establish optimal treatment approaches for GCED. |
| Publish Date |
2016-09-26 08:04 |
| Citation |
Matsumoto K, Ueyama H, Matsumoto K, Akazawa Y, Komori H, Takeda T, Murakami T, Asaoka D, Hojo M, Tomita N, Nagahara A, Kajiyama Y, Yao T, Watanabe S. Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World J Gastroenterol 2016; 22(36): 8203-8210 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i36/8203.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i36.8203 |
