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Articles Published Processes
9/8/2016 10:53:00 AM | Browse: 1186 | Download: 1990
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Received |
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2016-05-15 20:13 |
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Peer-Review Started |
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2016-05-17 17:10 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2016-06-20 15:53 |
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Revised |
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2016-07-05 07:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2016-07-21 10:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2016-08-01 14:14 |
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Articles in Press |
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2016-08-01 14:14 |
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Edit the Manuscript by Language Editor |
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2016-08-09 09:13 |
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Typeset the Manuscript |
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2016-08-30 17:07 |
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Publish the Manuscript Online |
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2016-09-08 10:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noha G Bader El Din, Sally Farouk, Reem El-Shenawy, Marwa K Ibrahim, Reham M Dawood, Mostafa M Elhady, Ahmed M Salem, Naglaa Zayed, Ahmed Khairy and Mostafa K El Awady |
| Funding Agency and Grant Number |
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| Corresponding Author |
Noha G Bader El Din, PhD, Professor of Medical Biotechnology, Department of Microbial Biotechnology, National Research Centre, 33 EL Bohouth Street (Former EL Tahrir Street), Dokki, Giza 12622, Egypt. nbadereldin@yahoo.com |
| Key Words |
Hepatitis C virus immune response; Tumor necrosis factor alpha; Single nucleotide polymorphisms; Cytokine expression; Liver disease progression |
| Core Tip |
Tumor necrosis factor alpha (TNFα) is a proinflammatory and antiviral cytokine that plays a major role in liver injury and initiation of the fibrosis process. We investigated the association of TNFα -G308A polymorphism with liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus (HCV) genotype 4. The results showed that the TNFα A allele produced high circulating TNFα in the body, which induces inflammatory response. The TNFα A allele was an independent risk factor for liver inflammation, steatosis and fibrosis. TNFα -G308A represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected patients. |
| Publish Date |
2016-09-08 10:53 |
| Citation |
Bader El Din NG, Farouk S, El-Shenawy R, Ibrahim MK, Dawood RM, Elhady MM, Salem AM, Zayed N, Khairy A, El Awady MK. Tumor necrosis factor- -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients. World J Gastroenterol 2016; 22(34): 7767-7777 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i34/7767.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i34.7767 |
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