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10/26/2016 5:33:00 PM | Browse: 876 | Download: 1551
Publication Name World Journal of Gastroenterology
Manuscript ID 28246
Country/Territory Japan
Received
2016-06-29 15:18
Peer-Review Started
2016-06-29 15:28
To Make the First Decision
2016-08-19 10:56
Return for Revision
2016-08-23 10:14
Revised
2016-09-06 15:46
Second Decision
2016-09-21 15:47
Accepted by Journal Editor-in-Chief
2016-09-22 17:04
Accepted by Company Editor-in-Chief
2016-09-28 17:51
Articles in Press
2016-09-28 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-17 20:16
Publish the Manuscript Online
2016-10-26 17:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Clinical Trials Study
Article Title Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Issei Saeki, Naoki Yamamoto, Takahiro Yamasaki, Taro Takami, Masaki Maeda, Koichi Fujisawa, Takuya Iwamoto, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Koichi Uchida, Kenji Tani and Isao Sakaida
Funding Agency and Grant Number
Funding Agency Grant Number
Grants-in-Aid for Scientific Research from the Japan Society for the Program of Science 23590978
Grants-in-Aid for Scientific Research from the Japan Society for the Program of Science 16H05287
Strategic Research Promotion Program from Yamaguchi University
Corresponding Author Takahiro Yamasaki, MD, PhD, Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami Kogushi, Ube, Yamaguchi 755-8505, Japan. t.yama@yamaguchi-u.ac.jp
Key Words Liver tumor; Hepatocellular carcinoma; Advanced stage; Iron-chelator; Deferasirox
Core Tip There are currently no established second-line chemotherapies for advanced hepatocellular carcinoma (HCC) patients. Iron chelators exert antiproliferative effects in several cancers. We demonstrated the inhibition of HCC by deferasirox (DFX) in the basic study. However, the efficacy of DFX in our clinical study could not be verified due to dose-limiting toxicities. Although iron chelators have promising therapeutic potential, further examinations are necessary to establish their clinical applications.
Publish Date 2016-10-26 17:34
Citation Saeki I, Yamamoto N, Yamasaki T, Takami T, Maeda M, Fujisawa K, Iwamoto T, Matsumoto T, Hidaka I, Ishikawa T, Uchida K, Tani K, Sakaida I. Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma. World J Gastroenterol 2016; 22(40): 8967-8977
URL http://www.wjgnet.com/1007-9327/full/v22/i40/8967.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i40.8967
Full Article (PDF) WJG-22-8967.pdf
Full Article (Word) WJG-22-8967.doc
Manuscript File 28246-Review.docx
Answering Reviewers 28246-Answering reviewers.pdf
Audio Core Tip 28246-Audio core tip.mp3
Clinical Trial Registration Statement 28246-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 28246-Conflict-of-interest statement.pdf
Copyright License Agreement 28246-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 28246-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 28246-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20160628114029.docx
Institutional Review Board Approval Form or Document 28246-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 28246-Langage certificate.pdf
Supplementary Material 28246-Supplementary material.pdf
Peer-review Report 28246-Peer-review(s).pdf
Scientific Misconduct Check 28246-Scientific misconduct check.pdf
Scientific Editor Work List 28246-Scientific editor work list.pdf