Publication Name	World Journal of Hepatology
Manuscript ID	28489
Country	United States

Received	2016-07-04 12:27
Peer-Review Started	2016-07-04 21:45
To Make the First Decision	2016-08-10 14:55
Return for Revision	2016-08-11 10:01
Revised	2016-09-02 00:53
Second Decision	2016-10-13 12:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-24 15:24
Articles in Press	2016-10-24 15:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-28 08:42
Publish the Manuscript Online	2016-12-06 08:34

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Case Control Study
Article Title	Fractional excretion of sodium in hepatorenal syndrome: Clinical and pathological correlation
Manuscript Source	Invited Manuscript
All Author List	Ali A Alsaad and Hani M Wadei
Funding Agency and Grant Number
Corresponding Author	Hani M Wadei, MD, Department of Transplant, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, United States. wadei.hani@mayo.edu
Key Words	Fractional excretion of sodium; Hepatorenal syndrome; Renal dysfunction; Liver transplantation; Urinary sodium excretion; Accuracy
Core Tip	In this retrospective analysis of patients with advanced end-stage liver disease, we describe three main concepts. First, our data indicates that fractional excretion of sodium (FeNa) < 1% is a common finding in this group of patients irrespective of the etiology of their renal dysfunction. Second, our study suggests that FeNa < 1% cannot differentiate hepatorenal syndrome (HRS) from other causes of renal pathology. And third, we statistically measured the performance of FeNa < 1% in patients with HRS using kidney biopsy findings as golden diagnostic standard.
Publish Date	2016-12-06 08:34
Citation	Alsaad AA, Wadei HM. Fractional excretion of sodium in hepatorenal syndrome: Clinical and pathological correlation. World J Hepatol 2016; 8(34): 1497-1501
URL	http://www.wjgnet.com/1948-5182/full/v8/i34/1497.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i34.1497

Full Article (PDF)	WJH-8-1497.pdf
Full Article (Word)	WJH-8-1497.doc
Manuscript File	28489-Review.docx
Answering Reviewers	28489-Answering reviewers.pdf
Audio Core Tip	28489-Audio core tip.mp3
Biostatistics Review Certificate	28489-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	28489-Conflict-of-interest statement.pdf
Copyright License Agreement	28489-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160701230517.docx
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20160701230545.docx
Institutional Review Board Approval Form or Document	28489-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28489-Langauage certificate.pdf
Peer-review Report	28489-Peer-review(s).pdf
Scientific Misconduct Check	28489-Scientific misconduct check.pdf
Scientific Editor Work List	28489-Scientific editor work list.pdf