Publication Name	World Journal of Hepatology
Manuscript ID	28671
Country	Japan

Received	2016-07-10 12:22
Peer-Review Started	2016-07-14 15:26
To Make the First Decision	2016-09-06 11:04
Return for Revision	2016-09-12 15:09
Revised	2016-09-25 17:34
Second Decision	2016-11-10 14:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-11-22 15:34
Articles in Press	2016-11-22 15:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-12-26 09:20
Publish the Manuscript Online	2017-01-06 08:51

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yuichi Torisu, Masanori Nakano, Keiko Takano, Ryo Nakagawa, Chisato Saeki, Atsushi Hokari, Tomohisa Ishikawa, Masayuki Saruta and Mikio Zeniya
Funding Agency and Grant Number
Corresponding Author	Yuichi Torisu, MD, Division of Gastro­enterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan. torisu@yb4.so-net.ne.jp
Key Words	Autoimmune hepatitis; Japanese patients; Adverse events; Corticosteroids; Ursodeoxycholic acid
Core Tip	Autoimmune hepatitis (AIH) is generally re-sponsive to immunosuppressive treatment, and cortico-steroids are commonly used for the initial and maintenance treatments. However, corticosteroid treatment must be discontinued in some patients because of several side effects. This study aimed to evaluate the therapeutic effects of ursodeoxycholic acid (UDCA), which has high tolerability and no severe side effects, on AIH. Our results suggest that to prevent adverse events related to corticosteroids, treatment with UDCA alone for AIH needs to be considered in selected patients, especially those with an alanine aminotransferase level of 200 IU/L or lower. This utility of UDCA must be confirmed in a prospective study.
Publish Date	2017-01-06 08:51
Citation	Torisu Y, Nakano M, Takano K, Nakagawa R, Saeki C, Hokari A, Ishikawa T, Saruta M, Zeniya M. Clinical usefulness of ursodeoxycholic acid for Japanese patients with autoimmune hepatitis. World J Hepatol 2017; 9(1): 57-63
URL	http://www.wjgnet.com/1948-5182/full/v9/i1/57.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i1.57

Full Article (PDF)	WJH-9-57.pdf
Full Article (Word)	WJH-9-57.doc
Manuscript File	28671-Review.docx
Answering Reviewers	28671-Answering reviewers.pdf
Audio Core Tip	28671-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	28671-Conflict-of-interest statement.pdf
Copyright License Agreement	28671-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	28671-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	28671-Language certificate.pdf
Peer-review Report	28671-Peer-review(s).pdf
Scientific Misconduct Check	28671-Scientific misconduct check.pdf
Scientific Editor Work List	28671-Scientific editor work list.pdf