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11/12/2016 1:33:00 PM | Browse: 392 | Download: 363
Publication Name World Journal of Gastroenterology
Manuscript ID 29424
Country/Territory United States
Received
2016-08-13 15:21
Peer-Review Started
2016-08-14 09:34
To Make the First Decision
2016-09-12 17:00
Return for Revision
2016-09-14 16:20
Revised
2016-10-07 02:09
Second Decision
2016-10-24 16:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-10-31 15:28
Articles in Press
2016-10-31 15:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-11-11 14:14
Publish the Manuscript Online
2016-11-12 13:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Frontier
Article Title Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis
Manuscript Source Invited Manuscript
All Author List Albert J Czaja
Funding Agency and Grant Number
Corresponding author Albert J Czaja, MD, Professor Emeritus, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street S.W., Rochester, MN 55905, United States. czaja.albert@mayo.edu
Keywords Intestinal microbiome; Inflammasomes; Autoimmune hepatitis; Dysbiosis; Toll-like receptors
Core Tip The intestinal microbiome is a reservoir of microbial antigens and activated immune cells that have been implicated in the pathogenesis of diverse systemic immune-mediated diseases. Dysbiosis, increased intestinal permeability, and molecular mimicry between microbial and self-antigens may initiate or sustain autoimmune hepatitis. Multiple drug, molecular, dietary, and probiotic interventions can modify the intestinal microbiome and attenuate the immune response. The role of the intestinal microbiome in autoimmune hepatitis warrants rigorous study, and new therapies may emerge that strengthen current treatment regimens.
Publish Date 2016-11-12 13:34
Citation Czaja AJ. Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis. World J Gastroenterol 2016; 22(42): 9257-9278
Url http://www.wjgnet.com/1007-9327/full/v22/i42/9257.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i42.9257
Full Article (PDF) WJG-22-9257.pdf
Full Article (Word) WJG-22-9257.doc
Manuscript File 29424-Review.docx
Answering Reviewers 29424-Answering reviewers.pdf
Audio Core Tip 29424-Audio core tip.mp3.mp3
Conflict-of-Interest Disclosure Form 29424-Conflict-of-interest statement.pdf
Copyright License Agreement 29424-Copyright assignment.pdf
Peer-review Report 29424-Peer-review(s).pdf
Scientific Misconduct Check 29424-Scientific misconduct check.pdf
Scientific Editor Work List 29424-Scientific editor work list.pdf