Publication Name	World Journal of Gastroenterology
Manuscript ID	29424
Country	United States

Received	2016-08-13 15:21
Peer-Review Started	2016-08-14 09:34
To Make the First Decision	2016-09-12 17:00
Return for Revision	2016-09-14 16:20
Revised	2016-10-07 02:09
Second Decision	2016-10-24 16:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-10-31 15:28
Articles in Press	2016-10-31 15:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-11-11 14:14
Publish the Manuscript Online	2016-11-12 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Frontier
Article Title	Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis
Manuscript Source	Invited Manuscript
All Author List	Albert J Czaja
Funding Agency and Grant Number
Corresponding Author	Albert J Czaja, MD, Professor Emeritus, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street S.W., Rochester, MN 55905, United States. czaja.albert@mayo.edu
Key Words	Intestinal microbiome; Inflammasomes; Autoimmune hepatitis; Dysbiosis; Toll-like receptors
Core Tip	The intestinal microbiome is a reservoir of microbial antigens and activated immune cells that have been implicated in the pathogenesis of diverse systemic immune-mediated diseases. Dysbiosis, increased intestinal permeability, and molecular mimicry between microbial and self-antigens may initiate or sustain autoimmune hepatitis. Multiple drug, molecular, dietary, and probiotic interventions can modify the intestinal microbiome and attenuate the immune response. The role of the intestinal microbiome in autoimmune hepatitis warrants rigorous study, and new therapies may emerge that strengthen current treatment regimens.
Publish Date	2016-11-12 13:34
Citation	Czaja AJ. Factoring the intestinal microbiome into the pathogenesis of autoimmune hepatitis. World J Gastroenterol 2016; 22(42): 9257-9278
URL	http://www.wjgnet.com/1007-9327/full/v22/i42/9257.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i42.9257

Full Article (PDF)	WJG-22-9257.pdf
Full Article (Word)	WJG-22-9257.doc
Manuscript File	29424-Review.docx
Answering Reviewers	29424-Answering reviewers.pdf
Audio Core Tip	29424-Audio core tip.mp3.mp3
Conflict-of-Interest Disclosure Form	29424-Conflict-of-interest statement.pdf
Copyright License Agreement	29424-Copyright assignment.pdf
Peer-review Report	29424-Peer-review(s).pdf
Scientific Misconduct Check	29424-Scientific misconduct check.pdf
Scientific Editor Work List	29424-Scientific editor work list.pdf