| ISSN |
2220-3168 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Masahiko Eto, Taro Takeshima, Masanori Harada, Shinji Fujiwara, Maki Kumada, Toyomi Kamesaki, Kazuhiro Takamura, Tsuneaki Kenzaka, Yoshikazu Nakamura, Takanori Aonuma, Masanobu Okayama and Eiji Kajii |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jichi Medical University 21st Century Center of Excellence Program from Minister Education, Culture, Sports, Science and Technology in Japan |
|
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| Corresponding Author |
Masanobu Okayama, MD, PhD, Division of Community Medicine and Medical Education, Kobe University Graduate School of Medicine, 2-1-5 Arata-sho, Hyogo-ku, Kobe 652-0032, Hyogo, Japan. okayama@jichi.ac.jp |
| Key Words |
Single nucleotide polymorphism; G-protein β3 subunit gene; Hypertension; Prehypertension |
| Core Tip |
The association of GNB3 gene polymorphism with hypertension has been examined in different populations. Unfortunately, the reported results have been controversial. This large-scale cross-sectional study of the Japanese population clarifies that among males aged ≤ 49 years, the TT single nucleotide polymorphism of GNB3 C825T is significantly associated with high systolic blood pressure (SBP) (≥ 130 mmHg). Therapeutic intervention is recommended at this level of SBP to prevent cardiovascular disease and its progression to hypertension. This approach is likely to be more effective for youngsters, compared to the elderly. This study suggests that using genetic information could make this approach more effective. |
| Publish Date |
2017-05-03 14:34 |
| Citation |
Eto M, Takeshima T, Harada M, Fujiwara S, Kumada M, Kamesaki T, Takamura K, Kenzaka T, Nakamura Y, Aonuma T, Okayama M, Kajii E. Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population. World J Hypertens 2017; 7(2): 24-31 |
| URL |
http://www.wjgnet.com/2220-3168/full/v7/i2/24.htm |
| DOI |
http://dx.doi.org/10.5494/wjh.v7.i2.24 |
