Publication Name	World Journal of Diabetes
Manuscript ID	3135
Country	United States

Received	2013-04-10 09:11
Peer-Review Started	2013-04-10 11:16
To Make the First Decision	2013-05-02 10:03
Return for Revision	2013-05-18 20:25
Revised	2013-05-22 03:28
Second Decision	2013-06-08 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-10 04:04
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-31 15:31
Publish the Manuscript Online	2013-08-15 11:51

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Field of Vision
Article Title	Status of autoimmune diabetes 20-year after generation of BDC2.5-TCR transgenic non-obese diabetic mouse
Manuscript Source	Invited Manuscript
All Author List	Lourdes Ramirez and Abdel Rahim A Hamad
Funding Agency and Grant Number	Funding Agency Grant Number NIH 1R56AI099027 NIH 1R01AI099027-01 American Heart Association 10GRNT4200003
Corresponding Author	Abdel Rahim A Hamad, Assistant Professor, Department of Pathology, Johns Hopkins University School of Medicine, Ross 664G, 720 Rutland Ave, Baltimore, MD 21205, United States. ahamad@jhmi.edu
Key Words	Autoimmune diabetes; Immunotherapy; T cells; BDC2.5 T cells; Anti-CD3; Immunosuppression
Core Tip	Our understanding of type 1 diabetes pathogenesis has significantly improved over the last three decades. We went from not knowing very little to acquisition of significant details about the role of the immune system and different T cell subsets in the disease process. The non-obese diabetic mouse model contributed and continues to contribute to our understanding of the disease process. This article pays tributes to the major role T-cells bearing-cell-specific T-cell receptors transgenic mouse played in shaping of our understanding of the disease process. We also divulge to briefly discuss current challenges facing development of a safe immunotherapy for the disease.
Publish Date	2013-08-15 11:51
Citation	Ramirez L, Hamad ARA. Status of autoimmune diabetes 20-year after generation of BDC2.5-TCR transgenic non-obese diabetic mouse. World J Diabetes 2013; 4(4): 88-91
URL	http://www.wjgnet.com/1948-9358/full/v4/i4/88.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i4.88

Full Article (PDF)	WJD-4-88.pdf
Manuscript File	3135-Review.docx
Answering Reviewers	3135-Answering reviewers.pdf
Copyright License Agreement	3135-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Final_copy_Hamad_#3135.docx
Peer-review Report	3135-Peer reviews.pdf
Scientific Editor Work List	3135-Scientific editor work list.doc