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Articles Published Processes
4/20/2017 3:58:56 PM | Browse: 1693 | Download: 2441
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Received |
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2016-11-22 10:10 |
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Peer-Review Started |
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2016-11-23 14:48 |
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To Make the First Decision |
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2016-12-19 09:53 |
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Return for Revision |
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2016-12-24 18:49 |
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Revised |
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2017-01-11 00:28 |
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Second Decision |
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2017-03-09 13:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-03-15 12:12 |
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Articles in Press |
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2017-03-15 12:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-04-13 08:48 |
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Publish the Manuscript Online |
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2017-04-20 15:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Changes in human hepatic metabolism in steatosis and cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zoe Schofield, Michelle AC Reed, Philip N Newsome, David H Adams, Ulrich L Günther and Patricia F Lalor |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health |
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| Corresponding Author |
Dr. Patricia F Lalor, Centre for Liver Research and National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit, Birmingham B152TT, United Kingdom. p.f.lalor@bham.ac.uk |
| Key Words |
Human; Liver; Metabolomics; Steatosis; Nuclear magnetic resonance; Alcohol |
| Core Tip |
We have for the first time performed a comparative analysis of 1H-NMR spectra from human liver derived from patients with different, but histologically similar etiologies, and steatotic donor tissue. In agreement with the fibrotic and inflammatory picture in the diseased livers, analytes relating to energy and protein metabolism and ketone body production were altered compared to the donor samples. More importantly, novel combinations of markers that may have diagnostic or prognostic significance were also identified by this approach. |
| Publish Date |
2017-04-20 15:58 |
| Citation |
Schofield Z, Reed MAC, Newsome PN, Adams DH, Günther UL, Lalor PF. Changes in human hepatic metabolism in steatosis and cirrhosis. World J Gastroenterol 2017; 23(15): 2685-2695 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i15/2685.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i15.2685 |
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