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Articles Published Processes
6/26/2017 10:23:06 AM | Browse: 822 | Download: 1453
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Received |
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2016-12-13 08:44 |
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Peer-Review Started |
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2016-12-14 08:32 |
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To Make the First Decision |
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2017-02-09 13:49 |
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Return for Revision |
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2017-02-10 10:10 |
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Revised |
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2017-02-25 03:37 |
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Second Decision |
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2017-04-11 18:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-04-12 18:43 |
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Articles in Press |
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2017-04-12 18:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-05-19 23:44 |
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Typeset the Manuscript |
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2017-06-15 10:08 |
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Publish the Manuscript Online |
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2017-06-26 10:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Luiz Domingues Almeida Junior, Ana Elisa Valencise Quaglio, Celso Acácio Rodrigues de Almeida Costa and Luiz Claudio Di Stasi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation (FAPESP) |
11/50512-2 |
| São Paulo Research Foundation (FAPESP) |
1515267-8 |
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| Corresponding Author |
Luiz Claudio Di Stasi, Professor, Laboratory of Phytomedicines, Pharmacology and Biotechnology (PhytoPharmaTech), Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista UNESP, Botucatu, São Paulo, CEP 18618-970, Brazil. ldistasi@ibb.unesp.br |
| Key Words |
Intestinal disease; Inflammatory bowel disease; Physalis angulata L. trinitrobenzenesulphonic acid |
| Core Tip |
We report, at the first time, the protective effects of a supercritical CO2 plant extract from aerial parts of Ground Cherry (Physalis angulata L.) in a model of intestinal inflammation induced by trinitrobenzenesulphonic acid in rats. The effects were related to presence of plant steroids, compounds chemically related to glucocorticoids, reference drugs used to treat human inflammatory bowel disease (IBD). The intestinal anti-inflammatory activity of Physalis angulata plant extract was related to its capacity to modulate oxidative stress, immune response and gene expression of inflammatory mediators. This way, the standardized plant extract of Ground Cherry enriched with phytosterols has potential for use to treat IBD. |
| Publish Date |
2017-06-26 10:23 |
| Citation |
Almeida Junior LD, Quaglio AEV, de Almeida Costa CAR, Di Stasi LC. Intestinal anti-inflammatory activity of Ground Cherry (Physalis angulata L.) standardized CO2 phytopharmaceutical preparation. World J Gastroenterol 2017; 23(24): 4369-4380 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i24/4369.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i24.4369 |
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