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Articles Published Processes
8/7/2017 9:17:02 AM | Browse: 1713 | Download: 3694
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Received |
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2017-02-15 15:07 |
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Peer-Review Started |
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2017-02-19 16:04 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2017-04-06 10:28 |
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Revised |
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2017-05-03 22:27 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-06-27 06:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-07-04 05:52 |
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Articles in Press |
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2017-07-04 05:52 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-07-31 09:22 |
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Publish the Manuscript Online |
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2017-08-07 09:17 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Domagoj Drmic, Danijela Kolenc, Spomenko Ilic, Lara Bauk, Marko Sever, Anita Zenko Sever, Kresimir Luetic, Jelena Suran, Sven Seiwerth and Predrag Sikiric |
| Funding Agency and Grant Number |
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| Corresponding Author |
Predrag Sikiric, MD, PhD, Professor, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Salata 11, POB 916, Zagreb 10000, Croatia. sikiric@mef.hr |
| Key Words |
BPC 157; celecoxib; L-arginine; N(G)-nitro-L-arginine methyl ester; rats |
| Core Tip |
In rats treated with the COX-2 inhibitor celecoxib, BPC 157 (given intraperitoneally) counteracted lesion development in the stomach, liver and brain. BPC 157 treatment alongside with N(G)-nitro-L-arginine methyl ester (L-NAME) also attenuated any effect of L-NAME that would otherwise have intensified the deleterious regular course. Consistently, with exacerbation (induced by L-NAME administration) and amelioration (due to L-arginine) of gastric, liver and brain lesions, L-arginine amelioration prevailed (i.e., the gastric, liver and brain lesions were attenuated) when given together with L-NAME (L-NAME + L-arginine), an effect further reversed toward a marked beneficial effect by the addition of BPC 157 (L-NAME + L-arginine + BPC 157). |
| Publish Date |
2017-08-07 09:17 |
| Citation |
Drmic D, Kolenc D, Ilic S, Bauk L, Sever M, Zenko Sever A, Luetic K, Suran J, Seiwerth S, Sikiric P. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME. World J Gastroenterol 2017; 23(29): 5304-5312
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| URL |
http://www.wjgnet.com/1007-9327/full/v23/i29/5304.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i29.5304 |
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