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8/7/2017 9:17:02 AM | Browse: 436 | Download: 458
Publication Name World Journal of Gastroenterology
Manuscript ID 33549
Country/Territory Croatia
2017-02-15 15:07
Peer-Review Started
2017-02-19 16:04
To Make the First Decision
2017-04-05 17:17
Return for Revision
2017-04-06 10:28
2017-05-03 22:27
Second Decision
2017-06-27 06:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-04 05:52
Articles in Press
2017-07-04 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-07-31 09:22
Publish the Manuscript Online
2017-08-07 09:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME
Manuscript Source Invited Manuscript
All Author List Domagoj Drmic, Danijela Kolenc, Spomenko Ilic, Lara Bauk, Marko Sever, Anita Zenko Sever, Kresimir Luetic, Jelena Suran, Sven Seiwerth and Predrag Sikiric
Funding Agency and Grant Number
Corresponding author Predrag Sikiric, MD, PhD, Professor, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Salata 11, POB 916, Zagreb 10000, Croatia. sikiric@mef.hr
Keywords BPC 157; celecoxib; L-arginine; N(G)-nitro-L-arginine methyl ester; rats
Core Tip In rats treated with the COX-2 inhibitor celecoxib, BPC 157 (given intraperitoneally) coun­teracted lesion development in the stomach, liver and brain. BPC 157 treatment alongside with N(G)-nitro-L-arginine methyl ester (L-NAME) also attenuated any effect of L-NAME that would otherwise have intensified the deleterious regular course. Consistently, with exacerbation (induced by L-NAME administration) and amelioration (due to L-arginine) of gastric, liver and brain lesions, L-arginine amelioration prevailed (i.e., the gastric, liver and brain lesions were attenuated) when given together with L-NAME (L-NAME + L-arginine), an effect further reversed toward a marked beneficial effect by the addition of BPC 157 (L-NAME + L-arginine + BPC 157).
Publish Date 2017-08-07 09:17
Citation Drmic D, Kolenc D, Ilic S, Bauk L, Sever M, Zenko Sever A, Luetic K, Suran J, Seiwerth S, Sikiric P. Celecoxib-induced gastrointestinal, liver and brain lesions in rats, counteraction by BPC 157 or L-arginine, aggravation by L-NAME. World J Gastroenterol 2017; 23(29): 5304-5312
Url http://www.wjgnet.com/1007-9327/full/v23/i29/5304.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i29.5304
Full Article (PDF) WJG-23-5304.pdf
Full Article (Word) WJG-23-5304.doc
Manuscript File 33549-Review.docx
Answering Reviewers 33549-Answering reviewers.pdf
Audio Core Tip 33549-Audio core tip.mp3
Biostatistics Review Certificate 33549-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 33549-Conflict-of-interest statement.pdf
Copyright License Agreement 33549-Copyright assignment.pdf
Data Sharing Statement 33549-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 33549_Ministarstvo poljoprivrede0001_0952.pdf
Institutional Review Board Approval Form or Document 33549-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33549-Language certificate.pdf
Scientific Research Process 33549-Scientific research process.pdf
Supplementary Material Supplementary_Material_20170215150552.docx
Peer-review Report 33549-Peer-review(s).pdf
Scientific Misconduct Check 33549-Scientific misconduct check.pdf
Scientific Editor Work List 33549-Scientific editor work list.pdf