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Articles Published Processes
9/12/2014 8:40:00 PM | Browse: 1356 | Download: 1518
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Received |
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2013-04-28 08:55 |
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Peer-Review Started |
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2013-04-28 21:19 |
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First Decision by Editorial Office Director |
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2013-06-02 19:53 |
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Revised |
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2013-07-18 18:03 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2013-08-08 19:21 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2013-08-09 01:02 |
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Articles in Press |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-09-29 15:43 |
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Publish the Manuscript Online |
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2013-10-15 17:26 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
New insights in bilirubin metabolism and their clinical implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eva Sticova and Milan Jirsa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project (Ministry of Health, Czech Republic) for Development of Research Organization |
00023001 |
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| Corresponding Author |
Sticova Eva, MD, Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 14021 Prague 4, Czech Republic. eva.sticova@ikem.cz |
| Key Words |
Hyperbilirubinemia; Hereditary jaundice; UGT1A1; ABCC2; Organic anion transporting polypeptide 1B1; Organic anion transporting polypeptide 1B3 |
| Core Tip |
Experiments with Oatp1a/1b-null mice and Oatp1a/1b; Abcc3 combination knockout mice plainly demonstrated that even under physiologic conditions a substantial portion of bilirubin glucuronides is not excreted directly into bile but is transported back to the blood by Abcc3. Oatp1a/1b activity accentuated in downstream (centrizonal) hepatocytes allows efficient reuptake of bilirubin conjugates, with a subsequent possibility being safely eliminated by excretion into bile. This and molecular findings in Rotor syndrome suggest that human transporters MRP3 and OATP1Bs form a sinusoidal liver-to-blood cycle which mediates shifting (hopping) of bilirubin and other substrates from periportal to centrizonal hepatocytes (References 18, 19, 22, 125).
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| Publish Date |
2013-10-15 17:26 |
| Citation |
Sticova E, Jirsa M. New insights in bilirubin metabolism and their clinical implications. World J Gastroenterol 2013; 19(38): 6398-6407 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i38/6398.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i38.6398 |
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