Publication Name	World Journal of Gastroenterology
Manuscript ID	34445
Country	China

Received	2017-05-04 10:06
Peer-Review Started	2017-05-04 21:48
To Make the First Decision	2017-06-05 00:58
Return for Revision	2017-06-07 00:08
Revised	2017-06-09 08:37
Second Decision	2017-07-05 23:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-07-12 06:23
Articles in Press	2017-07-12 06:23
Publication Fee Transferred	2017-07-14 03:14
Edit the Manuscript by Language Editor	2017-08-03 13:13
Typeset the Manuscript	2017-08-25 06:13
Publish the Manuscript Online	2017-09-07 08:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Retrospective Study
Article Title	Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy
Manuscript Source	Unsolicited Manuscript
All Author List	Gan Xie, Qian Zhou, Chuang-Zhao Qiu, Wen-Kui Dai, He-Ping Wang, Yin-Hu Li, Jian-Xiang Liao, Xin-Guo Lu, Su-Fang Lin, Jing-Hua Ye, Zhuo-Ya Ma and Wen-Jian Wang
ORCID	Author(s) ORCID Number Gan Xie http://orcid.org/0000-0001-6041-2523 Qian Zhou http://orcid.org/0000-0002-8433-2875 Chuang-Zhao Qiu http://orcid.org/0000-0001-5560-0992 Wen-Kui Dai http://orcid.org/0000-0002-9723-1416 He-Ping Wang http://orcid.org/0000-0002-9527-1334 Yin-Hu Li http://orcid.org/0000-0001-6378-6571 Jian-Xiang Liao http://orcid.org/0000-0001-9769-3365 Xin-Guo Lu http://orcid.org/0000-0002-8123-4081 Su-Fang Lin http://orcid.org/0000-0001-7430-7126 Jing-Hua Ye http://orcid.org/0000-0001-6525-5344 Zhuo-Ya Ma http://orcid.org/0000-0003-2538-9254 Wen-Jian Wang http://orcid.org/0000-0001-9459-3764
Funding Agency and Grant Number	Funding Agency Grant Number Shenzhen Science and Technology Innovation Committee JCYJ20150403100317071
Corresponding Author	Wen-Jian Wang, Doctor, Director for Department of Respiratory, Shenzhen Children’s Hospital, No.7019 Yitian Road, Shenzhen 518026, China. dhbk2005@163.com
Key Words	Ketogenic diet; Cronobacter; Seizures; Gut microbiota; Epilepsy
Core Tip	Many infants with epilepsy are refractory to current antiepileptic drugs, and ketogenic diet (KD) could help to moderate seizure frequency as an alternative treatment. A large number of reports have demonstrated that gut microbiota (GM) can affect children’s neurodevelopment. Concurrently, GM could be dramatically affected by diet. KD could rapidly alter GM and alleviate seizure frequency in infants with refractory epilepsy. The GM structure of epileptic infants - comprising large numbers of pathogens, such as Streptococcus - differed from that of healthy controls. After KD therapy, GM of epileptic patients changed significantly, with fewer pathogens and more beneficial bacteria.
Publish Date	2017-09-07 08:51
Citation	Xie G, Zhou Q, Qiu CZ, Dai WK, Wang HP, Li YH, Liao JX, Lu XG, Lin SF, Ye JH, Ma ZY, Wang WJ. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy. World J Gastroenterol 2017; 23(33): 6164-6171
URL	http://www.wjgnet.com/1007-9327/full/v23/i33/6164.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i33.6164

Full Article (PDF)	WJG-23-6164.pdf
Full Article (Word)	WJG-23-6164.doc
Manuscript File	34445-Review.docx
Answering Reviewers	34445-Answering reviewers.pdf
Audio Core Tip	34445-Audio core tip.WAV
Biostatistics Review Certificate	34445-Biostatistics Statement.pdf
Conflict-of-Interest Disclosure Form	34445-Conflict-of-interest statement.pdf
Copyright License Agreement	34445-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	34445-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	34445-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	34445-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	34445_34445-Language certificate.pdf
Supplementary Material	34445_34445-Supplementary Table.xlsx
Peer-review Report	34445-Peer-review(s).pdf
Scientific Misconduct Check	34445-Scientific misconduct check.pdf
Scientific Editor Work List	34445-Scientific editor work list.pdf