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10/16/2017 3:37:15 AM | Browse: 940 | Download: 1913
Publication Name World Journal of Hepatology
Manuscript ID 34680
Country/Territory Germany
Received
2017-05-26 00:57
Peer-Review Started
2017-05-27 00:13
To Make the First Decision
2017-07-10 00:33
Return for Revision
2017-07-11 02:44
Revised
2017-07-21 15:35
Second Decision
2017-08-10 03:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-05 01:47
Articles in Press
2017-09-05 01:47
Publication Fee Transferred
2017-09-07 19:27
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-10-13 03:27
Publish the Manuscript Online
2017-10-16 03:37
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study
Manuscript Source Unsolicited Manuscript
All Author List Dieter Melchart, Stefan Hager, Sabine Albrecht, Jingzhang Dai, Wolfgang Weidenhammer and Rolf Teschke
ORCID
Author(s) ORCID Number
Dieter Melchart http://orcid.org/orcid.org.0000-0001-9418-9761
Stefan Hager http://orcid.org/orcid.org.0000-0002-2896-7032
Sabine Albrecht http://orcid.org/orcid.org/0000-0003-1616-2760
Jingzhang Dai http://orcid.org/orcid.org/0000-0002-6739-8426
Wolfgang Weidenhammer http://orcid.org/orcid.org/0000-0002-5080-3448
Rolf Teschke http://orcid.org/orcid.org/0000-0001-8910-1200
Funding Agency and Grant Number
Corresponding Author Dieter Melchart, MD, Competence Centre for Complementary Medicine and Naturopathy (CoCoNat), University Hospital Munich rechts der Isar, Technical University of Munich, Kaiserstrasse 9, Munich D-80801, Germany. dieter.melchart@tum.de
Key Words Traditional Chinese Medicine; Herbal medicine; Liver injury; Roussel Uclaf Causality Assessment Method; Herb induced liver injury
Core Tip Worldwide research on herbal medicine safety is still limited. Adverse effects are range from clinically not relevant to more severe ones including suspected liver injury. We conducted a prospective hospital-based study to report the number of new liver injury in patients with no liver disease prior to treatment with herbal Traditional Chinese Medicine. Liver injury was detected in 26/21470 patients (0.12%) with alanine aminotransferase values of ≥ 5 × upper limit normal. The Roussel Uclaf Causality Assessment Method assessed the causality of suspected cases and showed a causality level of “possible” for the majority of the liver injury cases.
Publish Date 2017-10-16 03:37
Citation Melchart D, Hager S, Albrecht S, Dai J, Weidenhammer W, Teschke R. Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study. World J Hepatol 2017; 9(29): 1141-1157
URL http://www.wjgnet.com/1948-5182/full/v9/i29/1141.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i29.1141
Full Article (PDF) WJH-9-1141.pdf
Full Article (Word) WJH-9-1141.doc
Manuscript File 34680-Review.docx
Answering Reviewers 34680-Answering reviewers.pdf
Audio Core Tip 34680-Audio core tip.mp3
Biostatistics Review Certificate 34680-Biostatistics statement.pdf
Clinical Trial Registration Statement 34680-Clinical-Trial-Registration-Statement-revision.docx
Conflict-of-Interest Disclosure Form 34680-Conflict-of-interest statement.pdf
Copyright License Agreement 34680-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 34680-Approved-Grant-Application-Form(s)-or-Funding-Agency-Copy-of-any-Approval-Document(s)-revision.docx
Institutional Review Board Approval Form or Document 34680-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 34680-Language certificate.pdf
Supplementary Material 34680-Supplementary-Material-revision.docx
Peer-review Report 34680-Peer-review(s).pdf
Scientific Misconduct Check 34680-Scientific misconduct check.pdf
Scientific Editor Work List 34680-Scientific editor work list.pdf