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Articles Published Processes
12/26/2017 1:51:01 AM | Browse: 1308 | Download: 1184
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Received |
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2017-08-26 05:52 |
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Peer-Review Started |
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2017-08-26 12:18 |
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To Make the First Decision |
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2017-10-23 00:29 |
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Return for Revision |
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2017-10-24 03:53 |
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Revised |
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2017-10-30 16:01 |
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Second Decision |
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2017-11-20 02:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-28 02:05 |
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Articles in Press |
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2017-11-28 02:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-12-19 08:35 |
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Publish the Manuscript Online |
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2017-12-26 01:51 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria Dorobantu, Nicoleta-Monica Popa-Fotea, Mihaela Popa, Iulia Rusu and Miruna Mihaela Micheu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Miruna Mihaela Micheu, MD, PhD, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, Bucharest 014461, Romania. cardio@urgentafloreasca.ro |
| Key Words |
Stem cell therapy; Cardiac imaging techniques; Ischemic cardiac disease; Cardiac regeneration; End-points |
| Core Tip |
Although multiple studies have been published on stem cell therapy (SCT) in ischemic cardiac disease, no universal conclusion regarding its clinical efficacy has been given in part due to the lack of appropriate end-points. A rightful appreciation of SCT impact should be made considering multiple parameters from diverse categories, either objective - evaluating structural and biological functions, or subjective - patient orientated impacting daily quality of life. Current end-points, but also novel parameters investigating molecular pathways and new imaging methods with labelled cells genetically modified are being analytically discussed in this review, disclosing high heterogeneity in SCT efficacy assessment. |
| Publish Date |
2017-12-26 01:51 |
| Citation |
Dorobantu M, Popa-Fotea NM, Popa M, Rusu I, Micheu MM. Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease. World J Stem Cells 2017; 9(12): 203-218 |
| URL |
http://www.wjgnet.com/1948-0210/full/v9/i12/203.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v9.i12.203 |
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