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Articles Published Processes
1/14/2018 5:07:58 AM | Browse: 1130 | Download: 2052
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Received |
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2017-09-11 16:54 |
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Peer-Review Started |
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2017-09-12 07:56 |
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To Make the First Decision |
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2017-10-18 06:52 |
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Return for Revision |
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2017-10-23 11:50 |
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Revised |
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2017-11-03 07:37 |
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Second Decision |
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2017-11-21 11:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-21 18:48 |
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Articles in Press |
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2017-11-21 18:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-12-02 02:47 |
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Typeset the Manuscript |
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2018-01-05 07:02 |
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Publish the Manuscript Online |
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2018-01-14 05:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway mediated inflammation in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ping Jiang, Chun Xu, Yun-Wei Guo, Qian-Jiang Luo, Lin Li, Hui-Ling Liu, Jie Jiang, Hui-Xin Chen and Xiu-Qing Wei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81470848 |
| Breeding Foundation for Young Pioneers’ Research of Sun Yat-Sen University |
14ykpy27 |
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| Corresponding Author |
Xiu-Qing Wei, PhD, Professor, Department of Digestive Disease, Third Affiliated Hospital, Sun Yet-Sen University, Tianhe Road No. 600, Tianhe District, Guangzhou 510630, Guangdong Province, China. weixq@mail.sysu.edu.cn |
| Key Words |
Lipopolysaccharide; Liver injury; β-arrestin 2; TLR4/NF-κB signaling pathway; Pro-inflammatory cytokines |
| Core Tip |
The role and mechanism of β-arrestin 2 in lipopolysaccharide (LPS) -induced liver injury remains unclear. In this study, β-arrestin 2 KO mice displayed more severe LPS-induced liver injury and significantly higher levels of pro-inflammatory cytokines than wild-type mice. Further, RAW264.7 cells treated with β-arrestin 2 siRNA expressed significantly higher pro-inflammatory cytokines and molecules involved in the TLR4/NF-κB signaling pathway [including phospho-IкBα (p-IкBα) and phosho-p65 (p-p65)] than the control group at 6 h after treatment with LPS. Therefore, β-arrestin 2 could protect liver tissue from LPS-induced injury via inhibition of TLR4/NF-κB-mediated inflammation and may serve as a therapeutic target. |
| Publish Date |
2018-01-14 05:07 |
| Citation |
Jiang MP, Xu C, Guo YW, Luo QJ, Li L, Liu HL, Jiang J, Chen HX, Wei XQ. β-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice. World J Gastroenterol 2018; 24(2): 216-225 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i2/216.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i2.216 |
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