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12/20/2017 2:49:19 AM | Browse: 1264 | Download: 1785
Publication Name World Journal of Gastroenterology
Manuscript ID 36331
Country/Territory China
Received
2017-09-28 00:49
Peer-Review Started
2017-09-28 07:27
To Make the First Decision
2017-10-18 07:26
Return for Revision
2017-10-19 03:19
Revised
2017-11-14 06:07
Second Decision
2017-11-21 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-21 18:44
Articles in Press
2017-11-21 18:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-12-02 00:05
Typeset the Manuscript
2017-12-07 10:28
Publish the Manuscript Online
2017-12-20 02:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model
Manuscript Source Unsolicited Manuscript
All Author List Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo and Ning Dai
ORCID
Author(s) ORCID Number
Bin-Rui Chen http://orcid.org/0000-0002-4535-6516
Li-Jun Du http://orcid.org/0000-0002-7783-1959
Hui-Qin He http://orcid.org/0000-0002-0333-4933
John J Kim http://orcid.org/0000-0003-4341-8661
Yan Zhao http://orcid.org/0000-0003-4278-2592
Ya-Wen Zhang http://orcid.org/0000-0003-2191-3346
Liang Luo http://orcid.org/0000-0002-2630-5828
Ning Dai http://orcid.org/0000-0003-0749-9230
Funding Agency and Grant Number
Corresponding Author Ning Dai, PhD, Chief Doctor, Full Professor, Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. ndaicn@zju.edu.cn
Key Words Fructo-oligosaccharide; Stress; Irritable bowel syndrome; Visceral hypersensitivity; Intestinal inflammation; Short chain fatty acids; FODMAP
Core Tip Fructo-oligosaccharide is a component of Fermentable Oligosaccharides, Disaccharides, Mono­saccharides, and Polyols (FODMAP), which has been associated with triggering symptoms in patients with irritable bowel syndrome (IBS). In a stress-induced IBS mouse model, daily fructo-oligosaccharide (FOS) administration further intensified visceral hypersensitivity and low-grade intestinal inflammation compared to saline. FOS administration also led to increased intestinal production of individual and total short-chain fatty acids (SCFA) in mice subjected to stress. However, no difference in visceral sensitivity, intestinal inflammation, or cecal concentrations of SCFA was observed among sham-stressed mice receiving FOS or saline. Our findings suggest a mechanism of FODMAP-induced gastrointestinal symptoms associated with increased production of SCFA specific to IBS.
Publish Date 2017-12-20 02:49
Citation Chen BR, Du LJ, He HQ, Kim JJ, Zhao Y, Zhang YW, Luo L, Dai N. Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model. World J Gastroenterol 2017; 23(47): 8321-8333
URL http://www.wjgnet.com/1007-9327/full/v23/i47/8321.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i47.8321
Full Article (PDF) WJG-23-8321.pdf
Full Article (Word) WJG-23-8321.doc
Manuscript File 36331-Review.docx
Answering Reviewers 36331-Answering reviewers.pdf
Audio Core Tip 36331-Audio core tip.wav
Biostatistics Review Certificate 36331-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 36331-Conflict-of-interest statement.pdf
Copyright License Agreement 36331-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 36331-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.docx
Institutional Review Board Approval Form or Document 36331-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 36331-Language certificate.pdf
Supplementary Material 36331-Supplementary-Material-revision_4047.zip
Peer-review Report 36331-Peer-review(s).pdf
Scientific Misconduct Check 36331-Scientific misconduct check.pdf
Scientific Editor Work List 36331-Scientific editor work list.pdf