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Articles Published Processes
12/20/2017 2:49:19 AM | Browse: 1372 | Download: 2140
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Received |
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2017-09-28 00:49 |
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Peer-Review Started |
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2017-09-28 07:27 |
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To Make the First Decision |
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2017-10-18 07:26 |
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Return for Revision |
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2017-10-19 03:19 |
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Revised |
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2017-11-14 06:07 |
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Second Decision |
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2017-11-21 10:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2017-11-21 18:44 |
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Articles in Press |
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2017-11-21 18:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2017-12-02 00:05 |
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Typeset the Manuscript |
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2017-12-07 10:28 |
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Publish the Manuscript Online |
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2017-12-20 02:49 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0 |
Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo and Ning Dai |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Ning Dai, PhD, Chief Doctor, Full Professor, Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. ndaicn@zju.edu.cn |
Key Words |
Fructo-oligosaccharide; Stress; Irritable bowel syndrome; Visceral hypersensitivity; Intestinal inflammation; Short chain fatty acids; FODMAP |
Core Tip |
Fructo-oligosaccharide is a component of Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP), which has been associated with triggering symptoms in patients with irritable bowel syndrome (IBS). In a stress-induced IBS mouse model, daily fructo-oligosaccharide (FOS) administration further intensified visceral hypersensitivity and low-grade intestinal inflammation compared to saline. FOS administration also led to increased intestinal production of individual and total short-chain fatty acids (SCFA) in mice subjected to stress. However, no difference in visceral sensitivity, intestinal inflammation, or cecal concentrations of SCFA was observed among sham-stressed mice receiving FOS or saline. Our findings suggest a mechanism of FODMAP-induced gastrointestinal symptoms associated with increased production of SCFA specific to IBS. |
Publish Date |
2017-12-20 02:49 |
Citation |
Chen BR, Du LJ, He HQ, Kim JJ, Zhao Y, Zhang YW, Luo L, Dai N. Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model. World J Gastroenterol 2017; 23(47): 8321-8333 |
URL |
http://www.wjgnet.com/1007-9327/full/v23/i47/8321.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v23.i47.8321 |
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