Publication Name	World Journal of Gastroenterology
Manuscript ID	36331
Country	China

Received	2017-09-28 00:49
Peer-Review Started	2017-09-28 07:27
First Decision by Editorial Office Director	2017-10-18 05:34
Return for Revision	2017-10-19 03:19
Revised	2017-11-14 06:07
Publication Fee Transferred
Second Decision by Editor	2017-11-21 10:16
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-11-21 18:44
Articles in Press	2017-11-21 18:44
Edit the Manuscript by Language Editor	2017-12-02 00:05
Typeset the Manuscript	2017-12-07 10:28
Publish the Manuscript Online	2017-12-20 02:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model
Manuscript Source	Unsolicited Manuscript
All Author List	Bin-Rui Chen, Li-Jun Du, Hui-Qin He, John J Kim, Yan Zhao, Ya-Wen Zhang, Liang Luo and Ning Dai
ORCID	Author(s) ORCID Number Bin-Rui Chen http://orcid.org/0000-0002-4535-6516 Li-Jun Du http://orcid.org/0000-0002-7783-1959 Hui-Qin He http://orcid.org/0000-0002-0333-4933 John J Kim http://orcid.org/0000-0003-4341-8661 Yan Zhao http://orcid.org/0000-0003-4278-2592 Ya-Wen Zhang http://orcid.org/0000-0003-2191-3346 Liang Luo http://orcid.org/0000-0002-2630-5828 Ning Dai http://orcid.org/0000-0003-0749-9230
Funding Agency and Grant Number
Corresponding Author	Ning Dai, PhD, Chief Doctor, Full Professor, Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. ndaicn@zju.edu.cn
Key Words	Fructo-oligosaccharide; Stress; Irritable bowel syndrome; Visceral hypersensitivity; Intestinal inflammation; Short chain fatty acids; FODMAP
Core Tip	Fructo-oligosaccharide is a component of Fermentable Oligosaccharides, Disaccharides, Mono­saccharides, and Polyols (FODMAP), which has been associated with triggering symptoms in patients with irritable bowel syndrome (IBS). In a stress-induced IBS mouse model, daily fructo-oligosaccharide (FOS) administration further intensified visceral hypersensitivity and low-grade intestinal inflammation compared to saline. FOS administration also led to increased intestinal production of individual and total short-chain fatty acids (SCFA) in mice subjected to stress. However, no difference in visceral sensitivity, intestinal inflammation, or cecal concentrations of SCFA was observed among sham-stressed mice receiving FOS or saline. Our findings suggest a mechanism of FODMAP-induced gastrointestinal symptoms associated with increased production of SCFA specific to IBS.
Publish Date	2017-12-20 02:49
Citation	Chen BR, Du LJ, He HQ, Kim JJ, Zhao Y, Zhang YW, Luo L, Dai N. Fructo-oligosaccharide intensifies visceral hypersensitivity and intestinal inflammation in a stress-induced irritable bowel syndrome mouse model. World J Gastroenterol 2017; 23(47): 8321-8333
URL	http://www.wjgnet.com/1007-9327/full/v23/i47/8321.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i47.8321

Full Article (PDF)	WJG-23-8321.pdf
Full Article (Word)	WJG-23-8321.doc
Manuscript File	36331-Review.docx
Answering Reviewers	36331-Answering reviewers.pdf
Audio Core Tip	36331-Audio core tip.wav
Biostatistics Review Certificate	36331-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	36331-Conflict-of-interest statement.pdf
Copyright License Agreement	36331-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	36331-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.docx
Institutional Review Board Approval Form or Document	36331-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	36331-Language certificate.pdf
Supplementary Material	36331-Supplementary-Material-revision_4047.zip
Peer-review Report	36331-Peer-review(s).pdf
Scientific Misconduct Check	36331-Scientific misconduct check.pdf
Scientific Editor Work List	36331-Scientific editor work list.pdf