Publication Name	World Journal of Clinical Oncology
Manuscript ID	37263
Country	Italy

Received	2017-11-25 09:09
Peer-Review Started	2017-11-25 16:09
To Make the First Decision	2018-01-15 03:27
Return for Revision	2018-01-15 08:18
Revised	2018-02-02 12:38
Second Decision	2018-02-08 11:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-03-15 01:44
Articles in Press	2018-03-15 01:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-03-27 14:06
Publish the Manuscript Online	2018-04-11 01:34

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/bync/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives?
Manuscript Source	Invited Manuscript
All Author List	Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul and Bruna Scaggiante
ORCID	Author(s) ORCID Number Navid Sobhani http://orcid.org/0000-0003-1381-0283 Daniele Generali http://orcid.org/0000-0003-2480-3855 Fabrizio Zanconati http://orcid.org/0000-0001-5357-9579 Marina Bortul http://orcid.org/0000-0000-2510-79607 Bruna Scaggiante http://orcid.org/0000-0002-8662-138X
Funding Agency and Grant Number	Funding Agency Grant Number Ricerca Sanitaria 2015 LILT BEN2016/16
Corresponding Author	Bruna Scaggiante, PhD, Professor, Departement of Life Sciences, University of Trieste, Giorgeri 1, Trieste 34127, Italy. bscaggiante@units.it
Key Words	cfDNA integrity; Liquid biopsy; Breast cancer; ALU sequences; LINE-1 sequences
Core Tip	Despite the potentiality of cell-free DNA integrity as a useful tool for the monitoring of Breast Cancer (BC), evinced in some clinical studies, the scientific community has not reached agreeable conclusions to translate the results from the benchto-the-bedside yet. The main controversy regards the targets’ choice and the size of circulating cell-free tumor DNA fragments. This work underlines the utility of cell-free DNA Integrity evaluation for BC follow-up and at the same time highlights the common concepts explaining the different results in line of future directions.
Publish Date	2018-04-11 01:34
Citation	Sobhani N, Generali D, Zanconati F, Bortul M, Scaggiante B.Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives? World J Clin Oncol 2018; 9(2): 26-32
URL	http://www.wjgnet.com/2218-4333/full/v9/i2/26.htm
DOI	http://dx.doi.org/10.5306/wjco.v9.i2.26

Full Article (PDF)	WJCO-9-26.pdf
Full Article (Word)	WJCO-9-26.doc
Manuscript File	37263-Review.docx
Answering Reviewers	37263-Answering reviewers.pdf
Audio Core Tip	37263-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37263-Conflict-of-interest statement.pdf
Copyright License Agreement	37263-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	37263-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	37263-Language certificate.pdf
Peer-review Report	37263-Peer-review(s).pdf
Scientific Misconduct Check	37263-Scientific misconduct check.pdf
Scientific Editor Work List	37263-Scientific editor work list.pdf