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3/13/2018 8:32:30 AM | Browse: 414 | Download: 307
Publication Name World Journal of Gastroenterology
Manuscript ID 37880
Country/Territory South Korea
Received
2018-01-11 08:12
Peer-Review Started
2018-01-11 10:43
To Make the First Decision
2018-01-24 07:52
Return for Revision
2018-01-25 02:30
Revised
2018-01-31 07:17
Second Decision
2018-02-08 06:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-09 05:35
Articles in Press
2018-02-09 05:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-02-12 21:20
Typeset the Manuscript
2018-03-08 02:56
Publish the Manuscript Online
2018-03-13 08:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region
Manuscript Source Unsolicited Manuscript
All Author List Seoung-Ae Lee, So-Young Lee, Yu-Min Choi, Hong Kim and Bum-Joon Kim
ORCID
Author(s) ORCID Number
Seoung-Ae Lee http://orcid.org/0000-0002-4451-8165
So-Young Lee http://orcid.org/0000-0002-9638-893X
Yu-Min Choi http://orcid.org/0000-0003-4709-3155
Hong Kim http://orcid.org/0000-0003-1383-6803
Bum-Joon Kim http://orcid.org/0000-0003-0085-6709
Funding Agency and Grant Number
Funding Agency Grant Number
Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, South Korea HI14C0955
Corresponding author Bum-Joon Kim, PhD, Professor, Department of Biomedical Sciense, Microbiology and Immunology, and Liver Research Institute, Seoul National University, College of Medicine, 103, Daehak-ro, Jongno-gu, Seoul 110799, South Korea. kbumjoon@snu.ac.kr
Keywords Hepatitis B virus; W4P mutation of preS1; Transgenic mice; Hepatocellular carcinoma
Core Tip With the development of hepatitis B virus (HBV) vaccine, the rate of chronic HBV infection has dramatically declined worldwide. However, the incidence of hepatocellular carcinoma (HCC), which is characterized by poor prognosis and low survival rate, is on the rise. Predominance in males is a representative global epidemiological characteristic of HCC. Recently, we introduced the novel W4P substitution into the preS1 region, which associated with HCC and notably occurred exclusively in male patients. Our study in nude mouse xenograft model indicated that the W4P mutation likely contributed to IL-6-dependent HCC progression, particularly in male individuals. Here, to gain further insight into the role of this mutation in HBV-induced liver inflammation, we created transgenic mice carrying the full HBV genome with this mutation. Of note, our data showed that W4P transgene males of 10 mo of age, but not W4P transgene females, spontaneously developed liver damage due to IL-6-mediated liver inflammation, further supporting the previous finding regarding the contribution of the W4P mutation to gender disparity in susceptibility to HCC. Furthermore, our results prove the utility of the developed W4P transgene mouse model for the research into the mechanisms of HBV-caused liver diseases.
Publish Date 2018-03-13 08:32
Citation Lee SA, Lee SY, Choi YM, Kim H, Kim BJ. Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region. World J Gastroenterol 2018; 24(10): 1084-1092
Url http://www.wjgnet.com/1007-9327/full/v24/i10/1084.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i10.1084
Full Article (PDF) WJG-24-1084.pdf
Full Article (Word) WJG-24-1084.doc
Manuscript File 37880-Review.docx
Answering Reviewers 37880-Answering reviewers.pdf
Audio Core Tip 37880-Audio core tip.mp3
Biostatistics Review Certificate 37880-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 37880-Conflict-of-interest statement.pdf
Copyright License Agreement 37880-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 37880-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 37880-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 37880-Language certificate.pdf
Supplementary Material 37880-Supplementary material.pdf
Peer-review Report 37880-Peer-review(s).pdf
Scientific Misconduct Check 37880-Scientific misconduct check.pdf
Scientific Editor Work List 37880-Scientific editor work list.pdf