ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Authors 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Infectious Diseases |
Manuscript Type |
Observational Study |
Article Title |
Chronic hepatitis B virus monoinfection at a university hospital in Zambia
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Michael J Vinikoor, Edford Sinkala, Annie Kanunga, Mutinta Muchimba, Bright Nsokolo, Roma Chilengi, Gilles Wandeler, Joseph Mulenga, Tina Chisenga, Debika Bhattacharya, Michael S Saag, Graham Foster, Michael W Fried and Paul Kelly |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
School of Medicine at University of Alabama at Birmingham |
|
Fogarty International Center |
K01TW009998 |
National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health |
U01AI069924 |
Swiss National Science Foundation (to Wandeler G) |
PZ0093_154730 |
|
Corresponding Author |
Michael J Vinikoor, MD, Assistant Professor, Department of Medicine, University of Alabama at Birmingham, BBRB 256, 845 19th Street South, Birmingham, AL 35294, United States. mjv3@uab.edu |
Key Words |
Hepatitis B virus; Liver fibrosis; Treatment; Tenofovir; Africa |
Core Tip |
Data to inform the scale-up of hepatitis B testing and treatment in Africa are badly lacking. Among 120 recently diagnosed hepatitis B surface antigen-positive and HIV negative adults in Zambia, Southern Africa, 10% met the WHO’s criteria for immediate antiviral therapy and an additional 40% had an “indeterminate” hepatitis B virus (HBV) phenotype with either elevated alanine aminotransferase or HBV DNA > 2000 IU/ml. Among 40 additional patients who were antiviral therapy-experienced (primarily with tenofovir), tolerability and adherence were good; however, nearly half had incomplete HBV DNA suppression. Effective approaches to retain antiviral-ineligible HBV patients in care will be important in Zambia. |
Publish Date |
2018-09-27 09:38 |
Citation |
Vinikoor MJ, Sinkala E, Kanunga A, Muchimba M, Nsokolo B, Chilengi R, Wandeler G, Mulenga J, Chisenga T, Bhattacharya D, Saag MS, Foster G, Fried MW, Kelly P. Chronic hepatitis B virus monoinfection at a university hospital in Zambia. World J Hepatol 2018; 10(9): 622-628 |
URL |
http://www.wjgnet.com/1948-5182/full/v10/i9/622.htm |
DOI |
http://dx.doi.org/10.4254/wjh.v10.i9.622 |