Publication Name	World Journal of Critical Care Medicine
Manuscript ID	38872
Country	Netherlands

Received	2018-03-20 00:59
Peer-Review Started	2018-03-20 10:17
To Make the First Decision	2018-04-23 05:47
Return for Revision	2018-04-24 05:44
Revised	2018-06-19 09:18
Second Decision	2018-06-25 09:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-27 03:00
Articles in Press	2018-06-27 03:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-04 16:31
Typeset the Manuscript	2018-08-02 08:20
Publish the Manuscript Online	2018-08-06 06:44

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Evidence-Based Medicine
Article Title	Validation of the VitalPAC Early Warning Score at the Intermediate Care Unit
Manuscript Source	Unsolicited Manuscript
All Author List	Joost DJ Plate, Linda M Peelen, Luke PH Leenen and Falco Hietbrink
ORCID	Author(s) ORCID Number Joost DJ Plate http://orcid.org/0000-0003-4928-414X Linda M Peelen http://orcid.org/0000-0003-0269-0095 Luke PH Leenen http://orcid.org/0000-0001-8385-1801 Falco Hietbrink http://orcid.org/0000-0003-1462-6840
Funding Agency and Grant Number
Corresponding Author	Joost DJ Plate, MD, MSc, Research Scientist, Division of Surgery, University Medical Centre Utrecht, Utrecht University, Heidelberglaan 100, Utrecht 3584 CX, Netherlands. j.d.j.plate@umcutrecht.nl
Key Words	Intermediate Care Unit; High-dependency unit; Clinical deterioration; Vital signs; Early Warning Scoring
Core Tip	This study used all the routinely collected Early Warning Scores (EWS) in every nursing shift from 2014 to 2016 (n = 9113) at the standalone Intermediate Care Unit to assess the performance and clinical relevance of the EWS to detect clinical deterioration amongst patients admitted in this critical care facility. It follows that although the discriminative performance was acceptable (AUC 0.72), the clinical relevance is limited as 19 false alarms were needed to detect one event. As this may result in alarm fatigue, its use in this setting should be reconsidered.
Publish Date	2018-08-06 06:44
Citation	Plate JDJ, Peelen LM, Leenen LPH, Hietbrink F. Validation of the VitalPAC Early Warning Score at the Intermediate Care Unit. World J Crit Care Med 2018; 7(3): 39-45
URL	http://www.wjgnet.com/2220-3141/full/v7/i3/39.htm
DOI	http://dx.doi.org/10.5492/wjccm.v7.i3.39

Full Article (PDF)	WJCCM-7-39.pdf
Full Article (Word)	WJCCM-7-39.doc
PRISMA 2009 Checklist	38872-PRISMA 2009 Checklist.pdf
Manuscript File	38872-Review.docx
Answering Reviewers	38872-Answering reviewers.pdf
Audio Core Tip	38872-Audio core tip.mp3
Biostatistics Review Certificate	38872-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	38872-Conflict-of-interest statement.pdf
Copyright License Agreement	38872-Copyright license agreement.pdf
Supplementary Material	38872-Supplementary material.docx
Peer-review Report	38872-Peer-review(s).pdf
Scientific Misconduct Check	38872-Scientific misconduct check.pdf
Scientific Editor Work List	38872-Scientific editor work list.pdf