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9/27/2018 9:38:46 AM | Browse: 988 | Download: 1481
Publication Name World Journal of Hepatology
Manuscript ID 39254
Country United States
Received
2018-04-06 06:38
Peer-Review Started
2018-04-07 06:59
To Make the First Decision
2018-05-09 00:25
Return for Revision
2018-05-09 02:24
Revised
2018-05-09 07:05
Second Decision
2018-05-22 09:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-05-24 03:29
Articles in Press
2018-05-24 03:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-07-30 06:18
Publish the Manuscript Online
2018-09-27 09:38
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c
Manuscript Source Unsolicited Manuscript
All Author List Tien S Dong, Elizabeth S Aby, Jihane N Benhammou, Jenna Kawamoto, Steven-Huy Han, Folasade P May and Joseph R Pisegna
ORCID
Author(s) ORCID Number
Tien S Dong http://orcid.org/0000-0003-0105-8063
Elizabeth S Aby http://orcid.org/0000-0002-1809-2658
Jihane N Benhammou http://orcid.org/0000-0003-2442-5145
Jenna Kawamoto http://orcid.org/0000-0003-4879-5992
Steven-Huy Han http://orcid.org/0000-0003-1459-8763
Folasade P May http://orcid.org/0000-0001-6706-8171
Joseph R Pisegna http://orcid.org/0000-0002-5442-2474
Funding Agency and Grant Number
Corresponding Author Tien S Dong, MD, Academic Fellow, the Vatche and Tamar Manoukian Division of Digestive Diseases, University of California Los Angeles, Department of Medicine, University of California David Geffen School of Medicine, 10945 Le Conte Ave, PVUB 2114 MC694907, Los Angeles, CA 90095, United States. tsdong@mednet.ucla.edu
Key Words Hepatitis C virus; Hemoglobin A1c; Diabetes mellitus; Direct-acting antivirals; Metabolic syndrome
Core Tip The relationship of chronic hepatitis C virus (HCV) and type 2 diabetes mellitus is complex and lesser is known about its relationship to metabolic syndrome. While metabolic syndrome and type 2 diabetes may have had negative outcomes during the era of pegylated-interferon, research is being actively pursued to under­stand how direct acting antivirals (DAA) may affect these comorbidities. In this study, we show that unlike with pegylated-interferon, direct active antiviral success rates are not affected by the presence of metabolic syndrome. We further show that successful treatment of HCV with DAAs actually leads to better glycemic control 1-year post-treatment.
Publish Date 2018-09-27 09:38
Citation Dong TS, Aby ES, Benhammou JN, Kawamoto J, Han SH, May FP, Pisegna JR. Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c. World J Hepatol 2018; 10(9): 612-621
URL http://www.wjgnet.com/1948-5182/full/v10/i9/612.htm
DOI http://dx.doi.org/10.4254/wjh.v10.i9.612
Full Article (PDF) WJH-10-612.pdf
Full Article (Word) WJH-10-612.doc
Manuscript File 39254-Review.docx
Answering Reviewers 39254-Answering reviewers.pdf
Audio Core Tip 39254-Audio core tip.mp3
Biostatistics Review Certificate 39254-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39254-Conflict-of-interest statement.pdf
Copyright License Agreement 39254-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 39254-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 39254-Institutional review board statement.pdf
Supplementary Material 39254-Supplementary material.docx
Peer-review Report 39254-Peer-review(s).pdf
Scientific Misconduct Check 39254-Scientific misconduct check.pdf
Scientific Editor Work List 39254-Scientific editor work list.pdf