Publication Name	World Journal of Clinical Cases
Manuscript ID	40166
Country	Japan

Received	2018-06-22 07:44
Peer-Review Started	2018-06-22 08:29
First Decision by Editorial Office Director	2018-08-01 01:46
Return for Revision	2018-08-07 01:48
Revised	2018-09-01 04:26
Publication Fee Transferred
Second Decision by Editor	2018-09-03 08:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-10-08 21:25
Articles in Press	2018-10-08 21:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-19 10:29
Publish the Manuscript Online	2018-11-26 06:26

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Kazuya Miyaguchi, Minoru Yamaoka, Yoshikazu Tsuzuki, Keigo Ashitani, Hideki Ohgo, Yoshitaka Miyakawa, Keisuke Ishizawa, Hidekazu Kayano, Hidetomo Nakamoto and Hiroyuki Imaeda
ORCID	Author(s) ORCID Number Kazuya Miyaguchi http://orcid.org/0000-0003-0701-3608 Minoru Yamaoka http://orcid.org/0000-0003-2350-5223 Yoshikazu Tsuzuki http://orcid.org/0000-0003-3029-7469 Keigo Ashitani http://orcid.org/0000-0002-5043-892X Hideki Ohgo http://orcid.org/0000-0002-3916-2918 Yoshitaka Miyakawa http://orcid.org/0000-0002-4429-7227 Keisuke Ishizawa http://orcid.org/0000-0003-4751-7691 Hidekazu Kayano http://orcid.org/0000-0001-9349-4959 Hidetomo Nakamoto http://orcid.org/0000-0003-3975-5067 Hiroyuki Imaeda http://orcid.org/0000-0003-0898-6540
Funding Agency and Grant Number
Corresponding Author	Yoshikazu Tsuzuki, FACG, MD, PhD, Associate Professor, Department of Gastroenterology, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun 350-0495, Saitama, Japan. ytsuzuki@saitama-med.ac.jp
Key Words	Inflammatory bowel disease; Azathioprine; Virus-associated hemophagocytic syndrome; Ulcerative colitis; Case report
Core Tip	A 19-year-old female was diagnosed with ulcerative colitis, and has been receiving treatment with 5-aminosalicylic acid for 4 years, with additional azathioprine for 2 years. The patient experienced high-grade fever five d prior to presenting to the outpatient unit. She was diagnosed with Epstein-Barr virus-associated hemophagocytic syndrome (VAHS). VAHS is one of the rare and life-threatening pathophysiolo­gical conditions induced by thiopurine treatment. In such cases, early diagnosis is necessary, along with management of therapy, and related complications. When patients with inflammatory bowel disease, treated with immunomodulators such as thiopurine preparations, demonstrate high fever, VAHS should be considered in the differential diagnosis.
Publish Date	2018-11-26 06:26
Citation	Miyaguchi K, Yamaoka M, Tsuzuki Y, Ashitani K, Ohgo H, Miyagawa Y, Ishizawa K, Kayano H, Nakamoto H, Imaeda H. Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature. World J Clin Cases 2018; 6(14): 776-780
URL	http://www.wjgnet.com/2307-8960/full/v6/i14/776.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i14.776

Full Article (PDF)	WJCC-6-776.pdf
Full Article (Word)	WJCC-6-776.doc
CARE Checklist–2016	40166-CARE Checklist (2013).pdf
Manuscript File	40166-Review.docx
Answering Reviewers	40166-Answering reviewers.pdf
Audio Core Tip	40166-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40166-Conflict-of-interest statement.pdf
Copyright License Agreement	40166-Copyright license agreement.tif
Signed Informed Consent Form(s) or Document(s)	40166-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	40166-Language certificate.pdf
Peer-review Report	40166-Peer-review(s).pdf
Scientific Misconduct Check	40166-Scientific misconduct check.pdf
Scientific Editor Work List	40166-Scientific editor work list.pdf