Publication Name	World Journal of Clinical Cases
Manuscript ID	40807
Country	United States

Received	2018-07-10 01:31
Peer-Review Started	2018-07-10 05:30
To Make the First Decision	2018-08-01 03:30
Return for Revision	2018-08-03 02:07
Revised	2018-08-09 14:26
Second Decision	2018-08-28 10:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-28 15:27
Articles in Press	2018-08-28 15:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-02 19:38
Typeset the Manuscript	2018-10-24 09:09
Publish the Manuscript Online	2018-10-26 14:57

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	One more chance of fistula healing in inflammatory bowel disease: Stem cell therapy
Manuscript Source	Invited Manuscript
All Author List	Erica P. Turse, Francis E. Dailey, Maliha Naseer, Edward K. Partyka and Veysel Tahan
ORCID	Author(s) ORCID Number Erica P. Turse http://orcid.org/0000-0003-2270-2305 Francis E. Dailey http://orcid.org/0000-0001-8353-0709 Maliha Naseer http://orcid.org/0000-0001-6891-1378 Edward K. Partyka http://orcid.org/0000-0002-9415-7134 Veysel Tahan http://orcid.org/0000-0001-6796-9359
Funding Agency and Grant Number
Corresponding Author	Veysel Tahan, FACG, FACP, FEBG, MD, Assistant Professor, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Missouri, One Hospital Drive, CD 405, Columbia, MO 65212, United States. tahanv@health.missouri.edu
Key Words	Crohn’s disease; Stem cells; Mesenchymal; Fistulizing; Fistula; Inflammatory bowel disease
Core Tip	There appear to be limited adverse events as well as significant benefit to multi-approach therapy using stem cells to treat fistulizing inflammatory bowel disease. Comparing studies to current treatment rates of fistula healing, which has a less than 50% success rate, stem cell therapy for fistulizing Crohn’s disease ap­pears to be beneficial, as the majority of studies claim 60%-88% fistula healing and maintenance of remission at 24-52 wk. Further large-scale studies analyzing a multi-approach therapy including stem cells should be conducted, especially in a randomized double-blind approach.
Publish Date	2018-10-26 14:57
Citation	Turse EP, Dailey FE, Naseer M, Partyka EK. Tahan, V. One more chance of fistula healing in inflammatory bowel disease: Stem cell therapy. World J Clin Cases 2018; 6(12): 493-500
URL	http://www.wjgnet.com/2307-8960/full/v6/i12/493.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i12.493

Full Article (PDF)	WJCC-6-493.pdf
Full Article (Word)	WJCC-6-493.doc
Manuscript File	40807-Review.docx
Answering Reviewers	40807-Answering reviewers.pdf
Audio Core Tip	40807-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40807-Conflict-of-interest statement.pdf
Copyright License Agreement	40807-Copyright license agreement.pdf
Video	40807-Video-revision.docx
Peer-review Report	40807-Peer-review(s).pdf
Scientific Misconduct Check	40807-Scientific misconduct check.pdf
Scientific Editor Work List	40807-Scientific editor work list.pdf