Publication Name	World Journal of Gastroenterology
Manuscript ID	41325
Country	China

Received	2018-08-02 06:41
Peer-Review Started	2018-08-02 06:57
To Make the First Decision	2018-10-08 03:43
Return for Revision	2018-10-08 07:24
Revised	2018-10-17 08:58
Second Decision	2018-10-19 09:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-10-21 06:39
Articles in Press	2018-10-21 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-11-05 23:56
Typeset the Manuscript	2018-11-15 00:58
Publish the Manuscript Online	2018-11-21 04:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Jun Zhang, Yue Wu, Hao-Yi Jin, Shuai Guo, Zhe Dong, Zhi-Chao Zheng, Yue Wang and Yan Zhao
ORCID	Author(s) ORCID Number Jun Zhang http://orcid.org/0000-0003-1739-6462 Yue Wu http://orcid.org/0000-0002-2505-7842 Hao-Yi Jin http://orcid.org/0000-0002-6685-1102 Shuai Guo http://orcid.org/0000-0002-7418-6915 Zhe Dong http://orcid.org/0000-0002-2181-8173 Zhi-Chao Zheng http://orcid.org/0000-0003-1939-8138 Yue Wang http://orcid.org/0000-0003-4536-9904 Yan Zhao http://orcid.org/0000-0002-7760-916X
Funding Agency and Grant Number	Funding Agency Grant Number Liaoning S&T Project 2015020269
Corresponding Author	Yan Zhao, PhD, Professor, Department of Gastric Cancer, Liaoning Cancer Hospital and Institute (Cancer Hospital of China Medical University), No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. zhaoyan@cancerhosp-ln-cmu.com
Key Words	Stomach adenocarcinoma; The Cancer Genome Atlas; Weighted gene co-expression network analysis; Sorting nexin 10; Clinicopathological pre­dictors; Disease-free survival; Overall survival
Core Tip	This study used The Cancer Genome Atlas (TCGA) and clinical data to identify sorting nexin (SNX)10 as associated with poor prognosis in stomach adeno­carcinoma (SA). Firstly, we downloaded the TCGA-STAD RNA-seq data through R and identified the differentially expressed genes. Weighted gene co-expression network analysis was used to clarify the connection between modules and clinical information. We then chose SNX10 as the hub-gene of the tan-module after considering module membership, genes with high gene significance, degree and Molecular Complex Detection scores. Our center’s SA data were used to evaluate our hypothesis. Our findings demonstrated that weak expression of SNX10 is linked to poor SA prognosis.
Publish Date	2018-11-21 04:08
Citation	Zhang J, Wu Y, Jin HY, Guo S, Dong Z, Zheng ZC, Wang Y, Zhao Y. Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis. World J Gastroenterol 2018; 24(43): 4906-4919
URL	http://www.wjgnet.com/1007-9327/full/v24/i43/4906.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i43.4906

Full Article (PDF)	WJG-24-4906.pdf
Full Article (Word)	WJG-24-4906.doc
The ARRIVE Guidelines	41325-The ARRIVE guidelines.pdf
Manuscript File	41325-Review.docx
Answering Reviewers	41325-Answering reviewers.pdf
Audio Core Tip	41325-Audio core tip.m4a
Biostatistics Review Certificate	41325-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	41325-Conflict-of-interest statement.pdf
Copyright License Agreement	41325-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41325-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	41325-Institutional Animal Care and Use Committee Approval Form or Document.pdf
Institutional Review Board Approval Form or Document	41325-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	41325-Language certificate.pdf
Supplementary Material	41325-Supplementary material.pdf
Peer-review Report	41325-Peer-review(s).pdf
Scientific Misconduct Check	41325-Scientific misconduct check.pdf
Scientific Editor Work List	41325-Scientific editor work list.pdf