Publication Name	World Journal of Clinical Cases
Manuscript ID	41494
Country	Japan

Received	2018-08-20 09:20
Peer-Review Started	2018-08-21 03:26
To Make the First Decision	2018-10-12 00:27
Return for Revision	2018-10-12 06:49
Revised	2018-10-21 01:49
Second Decision	2018-10-22 08:30
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-10-22 21:35
Articles in Press	2018-10-22 21:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-11-19 08:01
Publish the Manuscript Online	2018-11-26 06:26

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Acquired hemophilia A in solid cancer: Two case reports and review of the literature
Manuscript Source	Unsolicited Manuscript
All Author List	Makoto Saito, Reiki Ogasawara, Koh Izumiyama, Akio Mori, Takeshi Kondo, Masanori Tanaka, Masanobu Morioka and Masahiro Ieko
ORCID	Author(s) ORCID Number Makoto Saito http://orcid.org/0000-0002-2683-9475 Reiki Ogasawara http://orcid.org/0000-0002-1136-5035 Koh Izumiyama http://orcid.org/0000-0002-0762-6255 Akio Mori http://orcid.org/0000-0002-2064-2145 Takeshi Kondo http://orcid.org/0000-0001-7455-5824 Masanori Tanaka http://orcid.org/0000-0002-8173-6620 Masanobu Morioka http://orcid.org/0000-0002-0784-8114 Masahiro Ieko http://orcid.org/0000-0003-1854-4543
Funding Agency and Grant Number
Corresponding Author	Makoto Saito, MD, PhD, Department of Internal Medicine and Hematology, Aiiku Hospital, Minami 4 Nishi 25 Chuo Ku, Sapporo 0640804, Hokkaido, Japan. ikyoku@aiiku-hp.or.jp
Key Words	Acquired hemophilia A; Coagulation factor Ⅷ; Solid cancer; Gastric cancer; Hepatocellular carcinoma; Case report
Core Tip	Acquired hemophilia A (AHA) is a rare he­morrhagic disease usually affecting the elderly, involving reduced coagulation factor Ⅷ activity. Malignancies are reported to occur in association with 10%-15% of patients with AHA. We report two cases of AHA in solid cancer, namely, gastric cancer and hepatocellular carcinoma. Hemostasis was fully achieved owing to eradication of inhibitor against factor Ⅷ, however, both patients died within 1 year due to cancer progression. Successful treatment for AHA in solid cancer can be difficult because not only active hemorrhage management and inhibitor eradica­tion but also treatment of the underlying malignancy is required.
Publish Date	2018-11-26 06:26
Citation	Saito M, Ogasawara R, Izumiyama K, Mori A, Kondo T, Tanaka M, Morioka M, Ieko M. Acquired hemophilia A in solid cancer: Two case reports and review of the literature. World J Clin Cases 2018; 6(14): 781-785
URL	http://www.wjgnet.com/2307-8960/full/v6/i14/781.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i14.781

Full Article (PDF)	WJCC-6-781.pdf
Full Article (Word)	WJCC-6-781.doc
CARE Checklist–2016	41494-CARE Checklist (2013).pdf
Manuscript File	41494-Review.docx
Answering Reviewers	41494-Answering reviewers.pdf
Audio Core Tip	41494-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41494-Conflict-of-interest statement.pdf
Copyright License Agreement	41494-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	41494-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	41494-Language certificate.pdf
Peer-review Report	41494-Peer-review(s).pdf
Scientific Misconduct Check	41494-Scientific misconduct check.pdf
Scientific Editor Work List	41494-Scientific editor work list.pdf