Publication Name	World Journal of Biological Chemistry
Manuscript ID	41750
Country	United States

Received	2018-08-28 02:50
Peer-Review Started	2018-08-28 12:06
To Make the First Decision	2018-09-11 08:05
Return for Revision	2018-09-11 09:11
Revised	2018-10-20 16:28
Second Decision	2018-11-01 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-03 03:59
Articles in Press	2018-11-03 03:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-05 07:32
Publish the Manuscript Online	2018-12-12 07:36

ISSN	1949-8454 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Arrestin-mediated signaling: Is there a controversy?
Manuscript Source	Invited Manuscript
All Author List	Vsevolod V Gurevich and Eugenia V Gurevich
ORCID	Author(s) ORCID Number Vsevolod V Gurevich http://orcid.org/0000-0002-3950-5351 Eugenia V Gurevich http://orcid.org/0000-0002-0563-8295
Funding Agency and Grant Number	Funding Agency Grant Number NIH EY011500 NIH GM122491 NIH NS065868 NIH DA030103
Corresponding Author	Vsevolod V Gurevich, PhD, Professor, Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, PRB Rm 417D, Nashville, TN 37232, United States. vsevolod.gurevich@vanderbilt.edu
Key Words	G protein-coupled receptors; Arrestin; G protein; Signaling; Extracellular signal–regulated kinase 1/2; c-Jun N-terminal kinase 3
Core Tip	Both arrestins and G proteins play important roles in G protein-coupled receptor (GPCR) signaling, including GPCR-initiated activation of mitogen-activated protein (MAP) kinases extracellular signal–regulated kinase (ERK)1/2 and c-Jun N-terminal kinase 3 (JNK3). Their roles do not overlap. G proteins participate in signal initiation, by activating MAP3Ks. Arrestins, free and GPCR-bound, function as scaffolds of the three-tiered MAP kinase cascades, facilitating signal transduction. Cells express other scaffolds, so that no MAPK cascade relies solely on arrestins. Different experimental paradigms highlight the role of G proteins or arrestins in this process, and neither can be discounted based on available evidence.
Publish Date	2018-12-12 07:36
Citation	Gurevich VV, Gurevich EV. Arrestin-mediated signaling: Is there a controversy? World J Biol Chem 2018; 9(3): 25-35
URL	https://www.wjgnet.com/1949-8454/full/v9/i3/25.htm
DOI	https://dx.doi.org/10.4331/wjbc.v9.i3.25

Full Article (PDF)	WJBC-9-25.pdf
Full Article (Word)	WJBC-9-25.doc
Manuscript File	41750-Review.docx
Answering Reviewers	41750-Answering reviewers.pdf
Audio Core Tip	41750-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	41750-Conflict-of-interest statement.pdf
Copyright License Agreement	41750-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	41750-Grant application form(s).pdf
Peer-review Report	41750-Peer-review(s).pdf
Scientific Misconduct Check	41750-Scientific misconduct check.pdf
Scientific Editor Work List	41750-Scientific editor work list.pdf