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1/16/2019 6:50:00 AM | Browse: 251 | Download: 253
Publication Name World Journal of Pharmacology
Manuscript ID 42393
Country/Territory United Kingdom
Received
2018-09-21 01:55
Peer-Review Started
2018-09-23 12:10
To Make the First Decision
2018-11-01 01:08
Return for Revision
2018-11-05 03:00
Revised
2018-11-17 08:35
Second Decision
2019-01-04 08:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-05 19:25
Articles in Press
2019-01-05 19:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-10 05:09
Publish the Manuscript Online
2019-01-16 06:50
ISSN 2220-3192 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pharmacology and Pharmacy
Manuscript Type Minireviews
Article Title Pharmacology and clinical applications of flupirtine: Current and future options
Manuscript Source Invited Manuscript
All Author List Kim Lawson
ORCID
Author(s) ORCID Number
Kim Lawson http://orcid.org/0000-0002-5458-1897
Funding Agency and Grant Number
Corresponding author Kim Lawson, PhD, Senior Lecturer, Department of Biosciences and Chemistry, Biomolecular Sciences Research Centre, Sheffield Hallam University, City Campus, Howard Street, Sheffield S1 1WB, United Kingdom. k.lawson@shu.ac.uk
Keywords Flupirtine; Kv7 channels; GABAA receptors; Analgesia; Seizures; Neuroprotection; Myotonia; Memory; Tinnitus
Core Tip Flupirtine exhibits pharmacological properties due to actions on Kv7 channels, G-protein-regulated inwardly rectifying K channels and γ-aminobutyric acid type A receptors leading to the suppression of over excitability of neuronal and non-neuronal cells. Consequently flupirtine has demonstrated efficacy consistent with use as an analgesic, an anticonvulsant, a neuroprotectant, skeletal and smooth muscle relaxant, in treatment of auditory and visual disorders, and treatment of memory and cognitive impairment. Flupirtine is providing important information and clues regarding novel mechanistic approaches to the treatment of a range of clinical conditions involving hyper-excitability of cells.
Publish Date 2019-01-16 06:50
Citation Lawson K. Pharmacology and clinical applications of flupirtine: Current and future options. World J Pharmacology 2019; 8(1): 1-13
Url https://www.wjgnet.com/2220-3192/full/v8/i1/1.htm
DOI https://dx.doi.org/10.5497/wjp.v8.i1.1
Full Article (PDF) WJP-8-1.pdf
Full Article (Word) WJP-8-1.docx
Manuscript File 42393-Review.docx
Answering Reviewers 42393-Answering reviewers.pdf
Audio Core Tip 42393-Audio core tip.wav
Conflict-of-Interest Disclosure Form 42393-Conflict-of-interest statement.pdf
Copyright License Agreement 42393-Copyright license agreement.pdf
Peer-review Report 42393-Peer-review(s).pdf
Scientific Misconduct Check 42393-Scientific misconduct check.pdf
Scientific Editor Work List 42393-Scientific editor work list.pdf