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Articles Published Processes
1/16/2019 6:50:00 AM | Browse: 1007 | Download: 1208
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Received |
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2018-09-21 01:55 |
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Peer-Review Started |
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2018-09-23 12:10 |
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To Make the First Decision |
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2018-11-01 01:08 |
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Return for Revision |
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2018-11-05 03:00 |
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Revised |
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2018-11-17 08:35 |
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Second Decision |
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2019-01-04 08:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-01-05 19:25 |
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Articles in Press |
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2019-01-05 19:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-01-10 05:09 |
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Publish the Manuscript Online |
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2019-01-16 06:50 |
| ISSN |
2220-3192 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Minireviews |
| Article Title |
Pharmacology and clinical applications of flupirtine: Current and future options
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kim Lawson |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kim Lawson, PhD, Senior Lecturer, Department of Biosciences and Chemistry, Biomolecular Sciences Research Centre, Sheffield Hallam University, City Campus, Howard Street, Sheffield S1 1WB, United Kingdom. k.lawson@shu.ac.uk |
| Key Words |
Flupirtine; Kv7 channels; GABAA receptors; Analgesia; Seizures; Neuroprotection; Myotonia; Memory; Tinnitus |
| Core Tip |
Flupirtine exhibits pharmacological properties due to actions on Kv7 channels, G-protein-regulated inwardly rectifying K channels and γ-aminobutyric acid type A receptors leading to the suppression of over excitability of neuronal and non-neuronal cells. Consequently flupirtine has demonstrated efficacy consistent with use as an analgesic, an anticonvulsant, a neuroprotectant, skeletal and smooth muscle relaxant, in treatment of auditory and visual disorders, and treatment of memory and cognitive impairment. Flupirtine is providing important information and clues regarding novel mechanistic approaches to the treatment of a range of clinical conditions involving hyper-excitability of cells. |
| Publish Date |
2019-01-16 06:50 |
| Citation |
Lawson K. Pharmacology and clinical applications of flupirtine: Current and future options. World J Pharmacology 2019; 8(1): 1-13 |
| URL |
https://www.wjgnet.com/2220-3192/full/v8/i1/1.htm |
| DOI |
https://dx.doi.org/10.5497/wjp.v8.i1.1 |
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