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1/14/2019 2:54:13 PM | Browse: 116 | Download: 84
Publication Name World Journal of Gastroenterology
Manuscript ID 42534
Country of Manuscript Source China
2018-10-16 03:19
Peer-Review Started
2018-10-16 08:29
To Make the First Decision
2018-11-22 06:26
Return for Revision
2018-11-22 07:43
2018-12-03 15:43
Second Decision
2018-12-13 08:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-13 17:41
Articles in Press
2018-12-13 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-20 12:39
Typeset the Manuscript
2019-01-14 00:20
Publish the Manuscript Online
2019-01-14 14:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Observational Study
Article Title Increased expression of brain derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List Yu Zhang, Geng Qin, De-Rong Liu, Yan Wang and Shu-Kun Yao
Author(s) ORCID Number
Yu Zhang http://orcid.org/0000-0003-0764-0599
Geng Qin http://orcid.org/0000-0002-1197-2011
De-Rong Liu http://orcid.org/0000-0002-7052-5246
Yan Wang http://orcid.org/0000-0002-9299-9418
Shu-Kun Yao http://orcid.org/0000-0002-8512-2589
Funding Agency and Grant Number
Funding Agency Grant Number
the National Key Technology Support Program during “12th Five-Year Plan” period of China 2014BAI08B00
the Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) Z171100001717008
Correspondence To Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Keywords Irritable bowel syndrome; Diarrhea; Brain-derived neurotrophic factor; Visceral hypersensitivity; Nerve growth
Core Tip This study comprehensively investigated the psychological and clinical characteristics and visceral sensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and further explored the levels of brain-derived neurotrophic factor (BDNF) protein and mRNA and nerve fiber density in the intestinal mucosa. It was demonstrated that the increased mucosal BDNF expression was positively correlated with the abdominal pain and disease severity and negatively correlated with visceral sensitivity parameters, which provides new evidence that BDNF may participate in the pathogenesis of IBS-D via facilitating mucosal nerve growth and increasing visceral sensitivity in IBS-D patients.
Publish Date 2019-01-14 14:54
Citation Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
Url https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i2.269
Full Article (PDF) WJG-25-269.pdf
Full Article (Word) WJG-25-269.docx
Manuscript File 42534-Review.docx
Answering Reviewers 42534-Answering reviewers.pdf
Audio Core Tip 42534-Audio core tip.mp3
Biostatistics Review Certificate 42534-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42534-Conflict-of-interest statement.pdf
Copyright License Agreement 42534-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42534-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 42534-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 42534-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42534-Language certificate.pdf
Peer-review Report 42534-Peer-review(s).pdf
Scientific Misconduct Check 42534-Scientific misconduct check.pdf
Scientific Editor Work List 42534-Scientific editor work list.pdf