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Articles Published Processes
1/14/2019 2:54:13 PM | Browse: 1243 | Download: 2409
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Received |
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2018-10-16 03:19 |
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Peer-Review Started |
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2018-10-16 08:29 |
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To Make the First Decision |
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2018-11-22 06:26 |
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Return for Revision |
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2018-11-22 07:43 |
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Revised |
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2018-12-03 15:43 |
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Second Decision |
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2018-12-13 08:59 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-13 17:41 |
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Articles in Press |
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2018-12-13 17:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-12-20 12:39 |
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Typeset the Manuscript |
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2019-01-14 00:20 |
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Publish the Manuscript Online |
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2019-01-14 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Increased expression of brain derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Zhang, Geng Qin, De-Rong Liu, Yan Wang and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Technology Support Program during “12th Five-Year Plan” period of China |
2014BAI08B00 |
| the Leap-forward Development Program for Beijing Biopharmaceutical Industry (G20) |
Z171100001717008 |
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| Corresponding Author |
Shu-Kun Yao, MD, PhD, Professor, Department of Gastroenterology, China-Japen Friendship Hospital, 2nd Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
Irritable bowel syndrome; Diarrhea; Brain-derived neurotrophic factor; Visceral hypersensitivity; Nerve growth |
| Core Tip |
This study comprehensively investigated the psychological and clinical characteristics and visceral sensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and further explored the levels of brain-derived neurotrophic factor (BDNF) protein and mRNA and nerve fiber density in the intestinal mucosa. It was demonstrated that the increased mucosal BDNF expression was positively correlated with the abdominal pain and disease severity and negatively correlated with visceral sensitivity parameters, which provides new evidence that BDNF may participate in the pathogenesis of IBS-D via facilitating mucosal nerve growth and increasing visceral sensitivity in IBS-D patients. |
| Publish Date |
2019-01-14 14:54 |
| Citation |
Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i2.269 |
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