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Articles Published Processes
1/14/2019 2:54:12 PM | Browse: 888 | Download: 1375
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Received |
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2018-10-18 04:17 |
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Peer-Review Started |
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2018-10-18 08:16 |
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To Make the First Decision |
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2018-11-01 06:57 |
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Return for Revision |
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2018-11-01 09:25 |
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Revised |
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2018-11-06 17:02 |
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Second Decision |
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2018-11-16 07:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-11-16 18:38 |
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Articles in Press |
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2018-11-16 18:38 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-01-14 00:10 |
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Publish the Manuscript Online |
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2019-01-14 14:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ausra Lukosiute-Urboniene, Aldona Jasukaitiene, Giedre Silkuniene, Vidmantas Barauskas, Antanas Gulbinas and Zilvinas Dambrauskas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ausra Lukosiute-Urboniene, MD, Doctor, Doctor, Surgeon, Institute for Digestive System Research, Lithuanian University of Health Sciences, Eiveniu Street 4, Kaunas 50161, Lithuania. ausra.urboniene2@lsmuni.lt |
| Key Words |
Pancreatic cancer; Inhibitors of apoptosis proteins; Human antigen R; Post-transcriptional regulation |
| Core Tip |
We report fundamental knowledge about the direct interaction of RNA stabilizing protein human antigen R (HuR) and inhibitor of apoptosis proteins (IAP1, IAP2). Results suggest that upregulation of IAP1 in pancreatic cancer is significantly related to poor outcomes. Furthermore, HuR plays important role in post-transcriptional regulation of these molecules: HuR protein binds with IAP1, IAP2 and after HuR silencing, IAP1 protein and mRNA expression is downregulated and IAP2 is upregulated. These results demonstrate, that HuR regulates expression of IAP1 and IAP2 in pancreatic cancer cells and that IAP1 may be an important factor facilitating carcinogenic properties of HuR. |
| Publish Date |
2019-01-14 14:54 |
| Citation |
Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z. Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. World J Gastroenterol 2019; 25(2): 205-219 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i2/205.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i2.205 |
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