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1/14/2019 2:54:12 PM | Browse: 132 | Download: 94
Publication Name World Journal of Gastroenterology
Manuscript ID 42941
Country of Manuscript Source Lithuania
Received
2018-10-18 04:17
Peer-Review Started
2018-10-18 08:16
To Make the First Decision
2018-11-01 06:57
Return for Revision
2018-11-01 09:25
Revised
2018-11-06 17:02
Second Decision
2018-11-16 07:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-16 18:38
Articles in Press
2018-11-16 18:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-14 00:10
Publish the Manuscript Online
2019-01-14 14:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer
Manuscript Source Unsolicited Manuscript
All Author List Ausra Lukosiute-Urboniene, Aldona Jasukaitiene, Giedre Silkuniene, Vidmantas Barauskas, Antanas Gulbinas and Zilvinas Dambrauskas
ORCID
Author(s) ORCID Number
Ausra Lukosiute-Urboniene http://orcid.org/0000-0002-6624-0686
Aldona Jasukaitiene http://orcid.org/0000-0002-4606-1963
Giedre Silkuniene http://orcid.org/0000-0001-8436-9718
Vidmantas Barauskas http://orcid.org/0000-0002-7332-5995
Antanas Gulbinas http://orcid.org/0000-0002-6683-1339
Zilvinas Dambrauskas http://orcid.org/0000-0003-2173-1294
Funding Agency and Grant Number
Corresponding author Ausra Lukosiute-Urboniene, MD, Doctor, Surgeon, Institute for Digestive System Research, Lithuanian University of Health Sciences, Eiveniu Street 4, Kaunas 50161, Lithuania. ausra.urboniene2@lsmuni.lt
Keywords Pancreatic cancer; Inhibitors of apoptosis proteins; Human antigen R; Post-transcriptional regulation
Core Tip We report fundamental knowledge about the direct interaction of RNA stabilizing protein human antigen R (HuR) and inhibitor of apoptosis proteins (IAP1, IAP2). Results suggest that upregulation of IAP1 in pancreatic cancer is significantly related to poor outcomes. Furthermore, HuR plays important role in post-transcriptional regulation of these molecules: HuR protein binds with IAP1, IAP2 and after HuR silencing, IAP1 protein and mRNA expression is downregulated and IAP2 is upregulated. These results demonstrate, that HuR regulates expression of IAP1 and IAP2 in pancreatic cancer cells and that IAP1 may be an important factor facilitating carcinogenic properties of HuR.
Publish Date 2019-01-14 14:54
Citation Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z. Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. World J Gastroenterol 2019; 25(2): 205-219
Url https://www.wjgnet.com/1007-9327/full/v25/i2/205.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i2.205
Full Article (PDF) WJG-25-205.pdf
Full Article (Word) WJG-25-205.docx
Manuscript File 41491-Review.docx
Answering Reviewers 42941-Answering reviewers.pdf
Audio Core Tip 42941-Audio core tip.mp3
Biostatistics Review Certificate 42941-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42941-Conflict-of-interest statement.pdf
Copyright License Agreement 42941-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 42941-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42941-Language certificate.pdf
Supplementary Material 42941-Supplementary-Material-revision.pptx
Peer-review Report 42941-Peer-review(s).pdf
Scientific Misconduct Check 42941-Scientific misconduct check.pdf
Scientific Editor Work List 42941-Scientific editor work list.pdf