| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jung Hwan Yoon, Yeon Soo Lee, Olga Kim, Hassan Ashktorab, Duane T Smoot, Suk Woo Nam and Won Sang Park |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
2018R1A2A2A14019713 |
|
| Corresponding Author |
Won Sang Park, MD, PhD, Doctor, Doctor, Professor, Department of Pathology, College of Medicine, The Catholic University of Korea, Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea. wonsang@catholic.ac.kr., Seoul 137-701, South Korea. wonsang@catholic.ac.kr |
| Key Words |
NKX6.3; Gastric mucosa; Atrophy; Amyloid β; Gastrokine 1 |
| Core Tip |
In human gastric epithelial cells, NKX6.3 depletion induced production of amyloid β (Aβ) oligomers, and also increased expression of apolipoprotein E (ApoE), Aβ, β-secretase 1 (Bace1), nicastrin, and receptor for advanced glycosylation end product proteins. Moreover, NKX6.3 depletion leads to stably formed of γ-secretase complex and binding to Bace1 protein. In gastric mucosae with atrophy, expression of Aβ oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Additionally, treatment with recombinant Aβ 1-42 produced oligomeric forms of Aβ and significantly decreased cell viability in NKX6.3 depleting cells. These observations provide evidences that NKX6.3 can inhibit gastric mucosal atrophy by regulating Aβ peptide accumulation and inflammatory reaction in gastric epithelial cells. |
| Publish Date |
2019-01-21 05:38 |
| Citation |
Yoon JH, Lee YS, Kim O, Ashktorab H, Smoot DT, Nam SW, Park WS. NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production. World J Gastroenterol 2019; 25(3): 330-345 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i3/330.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i3.330 |
