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Articles Published Processes
2/26/2019 9:05:11 AM | Browse: 857 | Download: 1676
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Received |
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2018-11-25 07:32 |
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Peer-Review Started |
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2018-11-26 10:36 |
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To Make the First Decision |
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2018-12-17 03:19 |
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Return for Revision |
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2018-12-21 04:29 |
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Revised |
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2018-12-24 14:59 |
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Second Decision |
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2018-12-29 05:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-12-30 02:28 |
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Articles in Press |
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2018-12-30 02:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-02-26 02:21 |
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Publish the Manuscript Online |
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2019-02-26 09:05 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Keita Kai, Yukie Yoda, Atsushi Kawaguchi, Akimichi Minesaki, Hironori Iwasaki, Shinichi Aishima and Hirokazu Noshiro |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Keita Kai, MD, PhD, Associate Professor, Department of Pathology, Saga University Hospital, 5-1-1 Nabeshima, Saga City, Saga 849-8501, Japan. kaikeit@cc.saga-u.ac.jp |
| Key Words |
Gastric cancer; Programmed death-ligand 1; Human epidermal growth factor receptor 2; Neutral buffered formalin; Fixation time |
| Core Tip |
We prospectively investigated the real effects of fixation conditions on HER-2 or PD-L1 testing for gastric cancer using 32 cases of gastrectomy specimens. We analysed these resected specimens dividing into four pieces and fixed in four strictly controlled different durations (6, 24, and 48 h, and 1 wk) by 10% formalin or 10% neutral buffered formalin. In this small-numbered pilot study, the prolonged fixation within 1 week showed no inferiority in HER-2 or PD-L1 testing. These results will provide supporting information for the interpretation of HER-2 and PD-L1 testing for prolonged fixation cases due to unavoidable circumstances. |
| Publish Date |
2019-02-26 09:05 |
| Citation |
Kai K, Yoda Y, Kawaguchi A, Minesaki A, Iwasaki H, Aishima S, Noshiro H. Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times. World J Clin Cases 2019; 7(4): 419-430 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i4/419.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i4.419 |
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