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4/13/2019 6:00:06 AM | Browse: 208 | Download: 250
Publication Name World Journal of Gastroenterology
Manuscript ID 44765
Country/Territory China
2019-01-13 05:31
Peer-Review Started
2019-01-14 07:10
To Make the First Decision
2019-02-14 02:13
Return for Revision
2019-02-14 05:22
2019-03-13 02:15
Second Decision
2019-03-15 09:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 17:58
Articles in Press
2019-03-16 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-25 05:34
Typeset the Manuscript
2019-04-04 01:54
Publish the Manuscript Online
2019-04-13 06:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients
Manuscript Source Unsolicited Manuscript
All Author List Xian-Xian Yuan, Hui-Juan Zhu, Hui Pan, Shi Chen, Ze-Yu Liu, Yue Li, Lin-Jie Wang, Lin Lu, Hong-Bo Yang and Feng-Ying Gong
Author(s) ORCID Number
Xian-Xian Yuan http://orcid.org/0000-0001-8762-8471
Hui-Juan Zhu http://orcid.org/0000-0001-5172-6870
Hui Pan http://orcid.org/0000-0003-2413-0646
Shi Chen http://orcid.org/0000-0002-6473-5511
Ze-Yu Liu http://orcid.org/0000-0001-7318-9340
Yue Li http://orcid.org/0000-0001-6799-1812
Lin-Jie Wang http://orcid.org/0000-0002-9548-0398
Lin Lu http://orcid.org/0000-0003-3379-8277
Hong-Bo Yang http://orcid.org/0000-0003-2985-8265
Feng-Ying Gong http://orcid.org/0000-0002-6361-3811
Funding Agency and Grant Number
Funding Agency Grant Number
the National Key Program of Clinical Science No. WBYZ 2011-873
the Chinese Academy of Medical Sciences Innovation Fund for Medical Science No. 2016YFC0901500
the Special Research Fund for Central Universities, Peking Union Medical College No. 2017PT31004
Corresponding author Hui-Juan Zhu, MD, Professor, Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission of the People's Republic of China, The Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. shengxin2004@163.com
Keywords Hypopituitarism; Nonalcoholic fatty liver disease; Cirrhosis; Diabetes insipidus; Plasma osmolality
Core Tip Fifty-four percent of hypopituitary patients in this retrospective study were diagnosed with non-alcoholic fatty liver disease (NAFLD), which was significantly higher than that of the general adult population in China. Growth hormone (GH) deficiency has been considered an important contributing factor to NAFLD in those patients. However, no significant differences were noted in GH and insulin-like growth factor 1 among patients with cirrhosis, subjects with NAFLD and those without NAFLD in this study. Interestingly, we found that the plasma osmolality and serum sodium concentration of the cirrhotic patients were significantly higher than those of the NAFLD patients. In addition, fasting insulin concentration was positively associated with plasma osmolality in patients with NAFLD. Additional studies are required to confirm that hyperosmolality may be a significant contributor to the worsening of NAFLD in hypopituitary patients.
Publish Date 2019-04-13 06:00
Citation Yuan XX, Zhu HJ, Pan H, Chen S, Liu ZY, Li Y, Wang LJ, Lu L, Yang HB, Gong FY. Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients. World J Gastroenterol 2019; 25(14): 1741-1752
Url https://www.wjgnet.com/1007-9327/full/v25/i14/1741.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i14.1741
Full Article (PDF) WJG-25-1741.pdf
Full Article (Word) WJG-25-1741.docx
Manuscript File 44765-Review_Edited.docx
Answering Reviewers 44765-Answering reviewers.pdf
Audio Core Tip 44765-Audio core tip.MP3
Biostatistics Review Certificate 44765-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44765-Conflict-of-interest statement.pdf
Copyright License Agreement 44765-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 44765-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 44765-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 44765-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 44765-Language certificate.pdf
Peer-review Report 44765-Peer-review(s).pdf
Scientific Misconduct Check 44765-Google-MA RY-1.png
Scientific Misconduct Check 44765-Google-MA RY-2.png
Scientific Misconduct Check 44765-Scientific misconduct check.pdf
Scientific Editor Work List 44765-Scientific editor work list.pdf