| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian-Xian Yuan, Hui-Juan Zhu, Hui Pan, Shi Chen, Ze-Yu Liu, Yue Li, Lin-Jie Wang, Lin Lu, Hong-Bo Yang and Feng-Ying Gong |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Key Program of Clinical Science |
No. WBYZ 2011-873 |
| the Chinese Academy of Medical Sciences Innovation Fund for Medical Science |
No. 2016YFC0901500 |
| the Special Research Fund for Central Universities, Peking Union Medical College |
No. 2017PT31004 |
|
| Corresponding Author |
Hui-Juan Zhu, MD, Professor, Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission of the People's Republic of China, The Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. shengxin2004@163.com |
| Key Words |
Hypopituitarism; Nonalcoholic fatty liver disease; Cirrhosis; Diabetes insipidus; Plasma osmolality |
| Core Tip |
Fifty-four percent of hypopituitary patients in this retrospective study were diagnosed with non-alcoholic fatty liver disease (NAFLD), which was significantly higher than that of the general adult population in China. Growth hormone (GH) deficiency has been considered an important contributing factor to NAFLD in those patients. However, no significant differences were noted in GH and insulin-like growth factor 1 among patients with cirrhosis, subjects with NAFLD and those without NAFLD in this study. Interestingly, we found that the plasma osmolality and serum sodium concentration of the cirrhotic patients were significantly higher than those of the NAFLD patients. In addition, fasting insulin concentration was positively associated with plasma osmolality in patients with NAFLD. Additional studies are required to confirm that hyperosmolality may be a significant contributor to the worsening of NAFLD in hypopituitary patients. |
| Publish Date |
2019-04-13 06:00 |
| Citation |
Yuan XX, Zhu HJ, Pan H, Chen S, Liu ZY, Li Y, Wang LJ, Lu L, Yang HB, Gong FY. Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients. World J Gastroenterol 2019; 25(14): 1741-1752 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i14/1741.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i14.1741 |
