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Articles Published Processes
5/6/2019 2:06:54 AM | Browse: 1076 | Download: 2707
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Received |
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2019-01-11 00:25 |
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Peer-Review Started |
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2019-01-11 00:29 |
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To Make the First Decision |
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2019-01-31 01:31 |
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Return for Revision |
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2019-01-31 01:36 |
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Revised |
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2019-02-15 16:17 |
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Second Decision |
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2019-02-22 09:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-02-23 05:15 |
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Articles in Press |
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2019-02-23 05:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-03-04 14:33 |
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Typeset the Manuscript |
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2019-04-25 00:40 |
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Publish the Manuscript Online |
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2019-05-06 02:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Hua Sun, Hong-Yan Wang, Shi-Dong Sun, Xin Zhang and Han Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Province Medical and Health Technology Development Project |
2014ws0020 |
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| Corresponding Author |
Shi-Dong Sun, MBChB, Attending Doctor, Chief Doctor, Director, Director, Department of Gastroenterology, PKUCare Luzhong Hospital, Taigong Road NO.65, Zibo 255400, Shandong Province, China. 18801235383@163.com |
| Key Words |
Proton pump inhibitors; Probiotics; Small intestinal bacterial overgrowth; Reflux esophagitis; Relapse |
| Core Tip |
Reflux esophagitis (RE) recurrences cause significant physical pain and financial burden to patients. Proton pump inhibitors (PPIs) are the first-line treatment for RE. Although PPIs provide notable symptomatic relief, their effects on the gut microbiota have drawn attention. In the present study, we evaluate the effectiveness of combining esomeprazole with probiotics [Bacillus subtilis (B. subtilis) and Enterococcus faecium (E. faecium)]. We found that the combined administration could reduce the incidence of small intestinal bacterial overgrowth and improve abdominal symptoms in patients with RE. It may also prolong the time to relapse, showing the potential of probiotics (B. subtilis and E. faecium) for the treatment and management of RE. |
| Publish Date |
2019-05-06 02:06 |
| Citation |
Sun QH, Wang HY, Sun SD, Zhang X, Zhang H. Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial. World J Gastroenterol 2019; 25(17): 2110-2121 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i17/2110.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i17.2110 |
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