Publication Name	World Journal of Gastroenterology
Manuscript ID	45680
Country	China

Received	2019-01-11 00:25
Peer-Review Started	2019-01-11 00:29
First Decision by Editorial Office Director	2019-01-30 06:24
Return for Revision	2019-01-31 01:36
Revised	2019-02-15 16:17
Publication Fee Transferred
Second Decision by Editor	2019-02-22 09:31
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2019-02-23 05:15
Articles in Press	2019-02-23 05:15
Edit the Manuscript by Language Editor	2019-03-04 14:33
Typeset the Manuscript	2019-04-25 00:40
Publish the Manuscript Online	2019-05-06 02:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Hua Sun, Hong-Yan Wang, Shi-Dong Sun, Xin Zhang and Han Zhang
ORCID	Author(s) ORCID Number Qing-Hua Sun http://orcid.org/0000-0001-5029-587X Hong-Yan Wang http://orcid.org/0000-0002-6837-5146 Shi-Dong Sun http://orcid.org/0000-0002-8945-9170 Xin Zhang http://orcid.org/0000-0001-9514-1292 Han Zhang http://orcid.org/0000-0002-3028-5460
Funding Agency and Grant Number	Funding Agency Grant Number Shandong Province Medical and Health Technology Development Project 2014ws0020
Corresponding Author	Shi-Dong Sun, MBChB, Attending Doctor, Chief Doctor, Director, Director, Department of Gastroenterology, PKUCare Luzhong Hospital, Taigong Road NO.65, Zibo 255400, Shandong Province, China. 18801235383@163.com
Key Words	Proton pump inhibitors; Probiotics; Small intestinal bacterial overgrowth; Reflux esophagitis; Relapse
Core Tip	Reflux esophagitis (RE) recurrences cause significant physical pain and financial burden to patients. Proton pump inhibitors (PPIs) are the first-line treatment for RE. Although PPIs provide notable symptomatic relief, their effects on the gut microbiota have drawn attention. In the present study, we evaluate the effectiveness of combining esomeprazole with probiotics [Bacillus subtilis (B. subtilis) and Enterococcus faecium (E. faecium)]. We found that the combined administration could reduce the incidence of small intestinal bacterial overgrowth and improve abdominal symptoms in patients with RE. It may also prolong the time to relapse, showing the potential of probiotics (B. subtilis and E. faecium) for the treatment and management of RE.
Publish Date	2019-05-06 02:06
Citation	Sun QH, Wang HY, Sun SD, Zhang X, Zhang H. Beneficial effect of probiotics supplements in reflux esophagitis treated with esomeprazole: A randomized controlled trial. World J Gastroenterol 2019; 25(17): 2110-2121
URL	https://www.wjgnet.com/1007-9327/full/v25/i17/2110.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i17.2110

Full Article (PDF)	WJG-25-2110.pdf
Full Article (Word)	WJG-25-2110.docx