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Articles Published Processes
5/28/2019 9:29:42 AM | Browse: 873 | Download: 1569
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Received |
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2019-02-12 08:56 |
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Peer-Review Started |
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2019-02-15 00:33 |
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To Make the First Decision |
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2019-04-08 01:15 |
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Return for Revision |
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2019-04-08 07:51 |
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Revised |
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2019-04-20 08:05 |
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Second Decision |
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2019-04-28 09:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-04-29 10:20 |
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Articles in Press |
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2019-04-29 10:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-04 22:57 |
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Typeset the Manuscript |
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2019-05-25 07:13 |
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Publish the Manuscript Online |
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2019-05-28 09:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-qi Yu, Wen-fei Wang, You-Chao Dai, Xin-Chun Chen and Jian-Yong Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Jiangxi Province, Key R&D Plan |
20171BBG70087 |
| Health Commission of Jiangxi Province |
20195016 |
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| Corresponding Author |
Jian-Yong Chen, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, Jiangxi Provincial People’s Hospital, 92 Aiguo Road, Donghu district, Nanchang 330006, Jiangxi Province, China. cjyacy69@163.com |
| Key Words |
Crohn’s disease; Intestinal tuberculosis; Single-nucleotide polymorphism; Interleukin-22; Interleukin-22 receptor 1; Multinucleated giant cells |
| Core Tip |
The interleukin-22 (IL22) gene promoter SNP rs2227473 G allele, located on the IL-23/IL-17 axis, is a risk factor for intestinal tuberculosis. High IL-22 expression seems to be a protective factor for intestinal tuberculosis. IL-22R1 is not only highly expressed in epithelial cells but also, unexpectedly, expressed in Langhans giant cells, contradicting the previous view that IL-22R1 is expressed in only non-haematopoietic cells. Importantly, these data provide a premise for elucidating the role of the IL-22/IL-22R1 system in the crosstalk between innate and adaptive immunity under conditions of chronic inflammation. Researchers should pay more attention to the immunological side effects of therapeutic modulation of the IL-22/IL-22R1 axis. |
| Publish Date |
2019-05-28 09:29 |
| Citation |
Yu ZQ, Wang WF, Dai YC, Chen XC, Chen JY. Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease. World J Gastroenterol 2019; 25(20): 2473-2488 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i20/2473.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i20.2473 |
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