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Articles Published Processes
11/15/2019 7:45:48 AM | Browse: 936 | Download: 1558
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Received |
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2019-03-14 00:56 |
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Peer-Review Started |
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2019-03-14 12:12 |
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To Make the First Decision |
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2019-05-28 03:00 |
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Return for Revision |
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2019-06-11 07:48 |
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Revised |
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2019-07-26 13:11 |
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Second Decision |
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2019-08-23 09:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-08-28 00:31 |
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Articles in Press |
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2019-08-28 00:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-09 18:32 |
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Typeset the Manuscript |
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2019-11-07 01:31 |
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Publish the Manuscript Online |
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2019-11-15 07:45 |
| ISSN |
1948-5204 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in Brazilian population.
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Manoela Dias Susi, Caroline de Matos Lourenço, Lucas Trevizani Rasmussen, Spencer Luis Marques Payão, Ana Flávia Teixeira Rossi, Ana Elizabete Silva and Juliana Garcia de Oliveira-Cucolo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FAPESP |
2013/14022-6 |
| FAPESP |
2014/17716-1 |
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| Corresponding Author |
Ana Elizabete Silva, PhD, Adjunct Professor, Department of Biology, São Paulo State University – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio Preto SP 15054-000, Brazil. ae.silva@unesp.br |
| Key Words |
Toll-like receptor 9; Helicobacter pylori; Gastric cancer; Chronic gastritis; Polymorphisms; Gene expression |
| Core Tip |
This study investigated the influence of the Toll-like receptor 9 (TLR9) polymorphisms on mRNA and Helicobacter pylori (H. pylori) infection in gastric cancer (GC) samples and the association of these single nucleotide polymorphisms with the risk of developing this neoplasm. Increased expression of TLR9 in tumor tissue was observed compared with chronic gastritis and normal tissue. Moreover, when the samples were grouped according to the H. pylori presence, an influence of this infection was observed on the upregulation of TLR9 mRNA expression. Thus, functional polymorphism in TLR9 and H. pylori infection may change gene expression levels, accentuating inflammation and aggravating the development of GC. |
| Publish Date |
2019-11-15 07:45 |
| Citation |
Susi MD, Lourenço CM, Rasmussen LT, Payão SLM, Rossi AFT, Silva AE, Oliveira-Cucolo JG. Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in Brazilian population. World J Gastrointest Oncol 2019; 11(11): 998-1010 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i11/998.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i11.998 |
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