Publication Name	World Journal of Hematology
Manuscript ID	47557
Country	Italy

Received	2019-03-18 05:21
Peer-Review Started	2019-03-19 09:21
To Make the First Decision	2019-09-18 01:47
Return for Revision	2019-09-19 01:49
Revised	2019-10-26 14:10
Second Decision	2019-12-05 08:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-12-08 23:25
Articles in Press	2019-12-08 23:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-19 09:06
Publish the Manuscript Online	2019-12-23 08:07

ISSN	2218-6204 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Hematology
Manuscript Type	Minireviews
Article Title	Adult Langerhans cell histiocytosis and immunomodulatory drugs: Review and analysis of thirty-four case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Endri Mauro, Piero Maria Stefani and Filippo Gherlinzoni
ORCID	Author(s) ORCID Number Endri Mauro http://orcid.org/0000-0002-4521-0998 Piero Maria Stefani http://orcid.org/0000-0003-3764-2165 Filippo Gherlinzoni http://orcid.org/0000-0002-9136-2108
Funding Agency and Grant Number
Corresponding Author	Endri Mauro, PhD, Doctor, Internal Medicine, Haematology Unit, Ospedale Cà Foncello, Piazzale Ospedale 1, Treviso 31100, Treviso, Italy. endri76@libero.it
Key Words	Langerhans cell histiocytosis; Immunomodulatory drugs; Thalidomide; Lenalidomide; ;
Core Tip	Langerhans cell histiocytosis (LCH) is a rare neoplastic disease derived from dendritic cells that is seen in children as well as in adults. There is not a standard first-line treatment in adults; no prospective trials have been undertaken on this population, and chemotherapy schedules are often reported from pediatric experiences with suboptimal efficacy and a higher toxicity in adults than in children. Immunomodulatory drugs (IMiDs), as less toxic therapeutic options, have been considered for treating LCH. We analyzed the efficacy and safety of IMiDs in adults with LCH from previously published research.
Publish Date	2019-12-23 08:07
Citation	Mauro E, Stefani PM, Gherlinzoni F. Adult Langerhans cell histiocytosis and immunomodulatory drugs: Review and analysis of thirty-four case reports. World J Hematol 2019; 8(1): 1-9
URL	https://www.wjgnet.com/2218-6204/full/v8/i1/1.htm
DOI	https://dx.doi.org/10.5315/wjh.v8.i1.1

Full Article (PDF)	WJH-8-1.pdf
Full Article (Word)	WJH-8-1.docx
Manuscript File	47557-Review.doc
Answering Reviewers	47557-Answering reviewers.pdf
Audio Core Tip	47557-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	47557-Conflict-of-interest statement.pdf
Copyright License Agreement	47557-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	47557-Language certificate.pdf
Peer-review Report	47557-Peer-review(s).pdf
Scientific Misconduct Check	47557-Scientific misconduct check.pdf
Scientific Editor Work List	47557-Scientific editor work list.pdf