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Articles Published Processes
5/28/2019 9:29:42 AM | Browse: 1048 | Download: 2117
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Received |
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2019-03-28 00:41 |
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Peer-Review Started |
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2019-03-28 05:35 |
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To Make the First Decision |
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2019-04-11 08:13 |
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Return for Revision |
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2019-04-12 05:58 |
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Revised |
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2019-05-07 09:13 |
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Second Decision |
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2019-05-08 08:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-08 16:01 |
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Articles in Press |
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2019-05-08 16:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-05-13 00:46 |
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Typeset the Manuscript |
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2019-05-25 07:08 |
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Publish the Manuscript Online |
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2019-05-28 09:29 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ze-Hua Zhao, Feng-Zhi Xin, Da Zhou, Ya-Qian Xue, Xiao-Lin Liu, Rui-Xu Yang, Qin Pan and Jian-Gao Fan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R and D Program of China |
2017YFC0908903 |
| National Natural Science Foundation of China |
81873565 |
| National Natural Science Foundation of China |
81470840 |
| National Natural Science Foundation of China |
81800510 |
| Shanghai Sailing Program |
18YF1415900 |
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| Corresponding Author |
Jian-Gao Fan, MD, PhD, Chief Doctor, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn |
| Key Words |
Gut microbiota; Trimethylamine N-oxide; Nonalcoholic steatohepatitis; Endoplasmic reticulum stress; Cholesterol |
| Core Tip |
The function of trimethylamine N-oxide (TMAO) in nonalcoholic steatohepatitis (NASH) remains unexplored. We investigate the effect of oral TMAO administration on the progression of NASH in a rat model induced by high-fat high-cholesterol (HFHC) diet. This study demonstrates for the first time that the gut microbial metabolite TMAO restores gut microbiota diversity, inhibits intestinal cholesterol absorption and reduces hepatic cholesterol overload, thus attenuating cholesterol-induced endoplasmic reticulum stress and hepatocyte cell death. These functions facilitate TMAO’s protection against HFHC diet-induced steatohepatitis in rats. |
| Publish Date |
2019-05-28 09:29 |
| Citation |
Zhao ZH, Xin FZ, Zhou D, Xue YQ, Liu XL, Yang RX, Pan Q, Fan JG. Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats. World J Gastroenterol 2019; 25(20): 2450-2462 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i20/2450.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i20.2450 |
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