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5/28/2019 9:29:42 AM | Browse: 242 | Download: 212
Publication Name World Journal of Gastroenterology
Manuscript ID 47797
Country/Territory China
Received
2019-03-28 00:41
Peer-Review Started
2019-03-28 05:35
To Make the First Decision
2019-04-11 08:13
Return for Revision
2019-04-12 05:58
Revised
2019-05-07 09:13
Second Decision
2019-05-08 08:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-08 16:01
Articles in Press
2019-05-08 16:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-05-13 00:46
Typeset the Manuscript
2019-05-25 07:08
Publish the Manuscript Online
2019-05-28 09:29
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats
Manuscript Source Unsolicited Manuscript
All Author List Ze-Hua Zhao, Feng-Zhi Xin, Da Zhou, Ya-Qian Xue, Xiao-Lin Liu, Rui-Xu Yang, Qin Pan and Jian-Gao Fan
ORCID
Author(s) ORCID Number
Ze-Hua Zhao http://orcid.org/0000-0002-3708-8881
Feng-Zhi Xin http://orcid.org/0000-0001-9674-0481
Da Zhou http://orcid.org/0000-0001-8838-1351
Ya-Qian Xue http://orcid.org/0000-0001-8641-8616
Xiao-Lin Liu http://orcid.org/0000-0003-4560-7589
Rui-Xu Yang http://orcid.org/0000-0001-9384-6408
Qin Pan http://orcid.org/0000-0001-5855-4952
Jian-Gao Fan http://orcid.org/0000-0001-7443-5056
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R and D Program of China 2017YFC0908903
National Natural Science Foundation of China 81873565
National Natural Science Foundation of China 81470840
National Natural Science Foundation of China 81800510
Shanghai Sailing Program 18YF1415900
Corresponding author Jian-Gao Fan, MD, PhD, Chief Doctor, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Keywords Gut microbiota; Trimethylamine N-oxide; Nonalcoholic steatohepatitis; Endoplasmic reticulum stress; Cholesterol
Core Tip The function of trimethylamine N-oxide (TMAO) in nonalcoholic steatohepatitis (NASH) remains unexplored. We investigate the effect of oral TMAO administration on the progression of NASH in a rat model induced by high-fat high-cholesterol (HFHC) diet. This study demonstrates for the first time that the gut microbial metabolite TMAO restores gut microbiota diversity, inhibits intestinal cholesterol absorption and reduces hepatic cholesterol overload, thus attenuating cholesterol-induced endoplasmic reticulum stress and hepatocyte cell death. These functions facilitate TMAO’s protection against HFHC diet-induced steatohepatitis in rats.
Publish Date 2019-05-28 09:29
Citation Zhao ZH, Xin FZ, Zhou D, Xue YQ, Liu XL, Yang RX, Pan Q, Fan JG. Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats. World J Gastroenterol 2019; 25(20): 2450-2462
Url https://www.wjgnet.com/1007-9327/full/v25/i20/2450.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i20.2450
Full Article (PDF) WJG-25-2450.pdf
Full Article (Word) WJG-25-2450.docx
Manuscript File 47797-Review_Edited.docx
Answering Reviewers 47797-Answering reviewers.pdf
Audio Core Tip 47797-Audio core tip.mp3
Biostatistics Review Certificate 47797-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47797-Conflict-of-interest statement.pdf
Copyright License Agreement 47797-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47797-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 47797-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 47797-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47797-Language certificate.pdf
Peer-review Report 47797-Peer-review(s).pdf
Scientific Misconduct Check 47797-Scientific misconduct check.pdf
Scientific Editor Work List 47797-Scientific editor work list.pdf