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12/10/2019 2:02:22 AM | Browse: 90 | Download: 97
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 48400
Country/Territory Spain
Received
2019-04-17 03:23
Peer-Review Started
2019-04-18 08:12
To Make the First Decision
2019-08-01 00:18
Return for Revision
2019-08-02 07:32
Revised
2019-08-18 23:05
Second Decision
2019-10-14 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-14 18:52
Articles in Press
2019-10-14 18:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-24 21:54
Typeset the Manuscript
2019-11-13 01:41
Publish the Manuscript Online
2019-12-10 02:02
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Genetics and Heredity
Manuscript Type Minireviews
Article Title Current status of the genetic susceptibility in attenuated adenomatous polyposis
Manuscript Source Invited Manuscript
All Author List Víctor Lorca and Pilar Garre
ORCID
Author(s) ORCID Number
Víctor Lorca http://orcid.org/0000-0002-3681-4319
Pilar Garre http://orcid.org/0000-0001-8285-4138
Funding Agency and Grant Number
Corresponding author Pilar Garre, PhD, Associate Specialist, Research Scientist, Laboratorio de Oncología Molecular, Servicio de Oncología, Hospital Clínico San Carlos, c/Profesor Martín Lagos s/n, Madrid 28040, Spain. pilar_garre@hotmail.com
Keywords Attenuated adenomatous polyposis; Genetic susceptibility; High predisposition gene; Genetic heterogeneity; Colorectal cancer;
Core Tip Attenuated adenomatous polyposis (AAP) is a highly genetically and clinically heterogeneous condition in terms of severity, clinical features and heritability as well as genetics. Major high predisposition genes, APC and MUTYH, explain a small fraction of AAP (10%-20%). Several predisposition genes have been recently proposed, and some of them have been validated, but their global contribution to the AAP genetic predisposition is scarce. Clinicians do not have strong discriminating criteria for the recommendation of the genetic testing, and the detection rate is low. Therefore, multigene panel testing and redefinition of strong clinical criteria could improve the outcome of the AAP genetic testing.
Publish Date 2019-12-10 02:02
Citation Lorca V, Garre P. Current status of the genetic susceptibility in attenuated adenomatous polyposis. World J Gastrointest Oncol 2019; 11(12): 1101-1114
Url https://www.wjgnet.com/1948-5204/full/v11/i12/1101.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i12.1101
Full Article (PDF) WJGO-11-1101.pdf
Full Article (Word) WJGO-11-1101.docx
Manuscript File FP7050_ce25_CE1MS-edit2_revisionPGR.docx
Answering Reviewers 48400-Answering reviewers.pdf
Audio Core Tip 48400-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 48400-Conflict-of-interest statement.pdf
Copyright License Agreement 48400-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 48400-Language certificate.pdf
Peer-review Report 48400-Peer-review(s).pdf
Scientific Misconduct Check 48400-Scientific misconduct check.pdf
Scientific Editor Work List 48400-Scientific editor work list.pdf