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Articles Published Processes
12/10/2019 2:02:22 AM | Browse: 723 | Download: 1105
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Received |
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2019-04-17 03:23 |
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Peer-Review Started |
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2019-04-18 08:12 |
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To Make the First Decision |
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2019-08-01 00:18 |
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Return for Revision |
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2019-08-02 07:32 |
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Revised |
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2019-08-18 23:05 |
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Second Decision |
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2019-10-14 09:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-14 18:52 |
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Articles in Press |
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2019-10-14 18:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-24 21:54 |
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Typeset the Manuscript |
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2019-11-13 01:41 |
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Publish the Manuscript Online |
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2019-12-10 02:02 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Minireviews |
| Article Title |
Current status of the genetic susceptibility in attenuated adenomatous polyposis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Víctor Lorca and Pilar Garre |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Pilar Garre, PhD, Manager, Research Scientist, Laboratorio de Oncología Molecular, Servicio de Oncología, Hospital Clínico San Carlos, c/Profesor Martín Lagos s/n, Madrid 28040, Spain. pilar_garre@hotmail.com |
| Key Words |
Attenuated adenomatous polyposis; Genetic susceptibility; High predisposition gene; Genetic heterogeneity; Colorectal cancer; |
| Core Tip |
Attenuated adenomatous polyposis (AAP) is a highly genetically and clinically heterogeneous condition in terms of severity, clinical features and heritability as well as genetics. Major high predisposition genes, APC and MUTYH, explain a small fraction of AAP (10%-20%). Several predisposition genes have been recently proposed, and some of them have been validated, but their global contribution to the AAP genetic predisposition is scarce. Clinicians do not have strong discriminating criteria for the recommendation of the genetic testing, and the detection rate is low. Therefore, multigene panel testing and redefinition of strong clinical criteria could improve the outcome of the AAP genetic testing. |
| Publish Date |
2019-12-10 02:02 |
| Citation |
Lorca V, Garre P. Current status of the genetic susceptibility in attenuated adenomatous polyposis. World J Gastrointest Oncol 2019; 11(12): 1101-1114 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i12/1101.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i12.1101 |
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